PrPC Governs Susceptibility to Prion Strains in Bank Vole, While Other Host Factors Modulate Strain Features

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2016 Sep 23

PMID 27654300

Citations 26

Authors

J C Espinosa

R Nonno

M Di Bari

P Aguilar-Calvo

L Pirisinu

N Fernandez-Borges

I Vanni

G Vaccari

A Marin-Moreno

P Frassanito

P Lorenzo

U Agrimi

J M Torres

Affiliations

Soon will be listed here.

Abstract

Importance: The differential susceptibility of bank voles to prion strains can be modeled in transgenic mice, suggesting that this selective susceptibility is controlled by the vole PrP sequence alone rather than by other species-specific factors. Differences in the phenotypes observed after prion transmissions in bank voles and in the transgenic mice suggest that host factors other than the PrP sequence may affect the selection of the substrain replicating in the animal model.

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