Prion Protein Alleles Showing a Protective Effect on the Susceptibility of Sheep to Scrapie and Bovine Spongiform Encephalopathy

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2007 Apr 20

PMID 17442723

Citations 26

Authors

Gabriele Vaccari

Claudia DAgostino

Romolo Nonno

Francesca Rosone

Michela Conte

Michele Angelo Di Bari

Barbara Chiappini

Elena Esposito

Luigi De Grossi

Francesco Giordani

Stefano Marcon

Luisella Morelli

Renata Borroni

Umberto Agrimi

Affiliations

Soon will be listed here.

Abstract

The susceptibility of sheep to classical scrapie and bovine spongiform encephalopathy (BSE) is mainly influenced by prion protein (PrP) polymorphisms A136V, R154H, and Q171R, with the ARR allele associated with significantly decreased susceptibility. Here we report the protective effect of the amino acid substitution M137T, I142K, or N176K on the ARQ allele in sheep experimentally challenged with either scrapie or BSE. Such observations suggest the existence of additional PrP alleles that significantly decrease the susceptibility of sheep to transmissible spongiform encephalopathies, which may have important implications for disease eradication strategies.

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