Clinical Comparison of Single-oral-dose Cefuroxime Axetil and Amoxicillin with Probenecid for Uncomplicated Gonococcal Infections in Women

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1989 Jun 1

PMID 2764526

Citations 6

Authors

L M Baddour

R S Gibbs

G Mertz

D M Cocchetto

R C Noble

Affiliations

Soon will be listed here.

Abstract

Four hundred sixty-six female patients were enrolled in a randomized study that compared the clinical efficacies of single oral doses of cefuroxime axetil and amoxicillin with probenecid in the treatment of uncomplicated gonorrhea. Two hundred ninety-five patients had culture-positive gonococcal infections and completed the investigation. Cure rates for the patients treated with cefuroxime axetil and those treated with amoxicillin with probenecid were high (greater than 95%) for genitorectal infections. Pharyngeal infections, however, were not uniformly eradicated by either cefuroxime axetil (60%) or amoxicillin with probenecid (64%). Approximately 13% of each patient group suffered adverse events, which were gastrointestinal in the majority and were transient. Compared with amoxicillin plus probenecid, cefuroxime axetil in a single oral dose was an equally safe and effective drug for the treatment of uncomplicated gonorrhea in women caused by penicillin-susceptible strains.

Citing Articles

Cefuroxime axetil (ceftin): a brief review.

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Cefuroxime axetil: an updated review of its use in the management of bacterial infections.

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Prepackaged therapy for urethritis: the "MSTOP" experience in Cameroon.

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Comparison of single-dose cefuroxime axetil with ciprofloxacin in treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing Neisseria gonorrhoeae strains.

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