Multimodal Population Brain Imaging in the UK Biobank Prospective Epidemiological Study

Overview

Journal Nat Neurosci

Date 2016 Sep 20

PMID 27643430

Citations 818

Authors

Karla L Miller

Fidel Alfaro-Almagro

Neal K Bangerter

David L Thomas

Essa Yacoub

Junqian Xu

Andreas J Bartsch

Saad Jbabdi

Stamatios N Sotiropoulos

Jesper L R Andersson

Ludovica Griffanti

Gwenaelle Douaud

Thomas W Okell

Peter Weale

Iulius Dragonu

Steve Garratt

Sarah Hudson

Rory Collins

Mark Jenkinson

Paul M Matthews

Stephen M Smith

Affiliations

Soon will be listed here.

Abstract

Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank.

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