Integrating Cardiomyocytes from Human Pluripotent Stem Cells in Safety Pharmacology: Has the Time Come?

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2016 Sep 20

PMID 27641943

Citations 60

Authors

Luca Sala

Milena Bellin

Christine L Mummery

Affiliations

Soon will be listed here.

Abstract

Linked Articles: This article is part of a themed section on New Insights into Cardiotoxicity Caused by Chemotherapeutic Agents. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.21/issuetoc.

Citing Articles

Anticholinergic drugs and dementia risk: Using stem cell-based studies to complement pharmacoepidemiology.

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PMID: 39911736 PMC: 11795422. DOI: 10.1002/trc2.70040.

Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes.

Oh J, Kwon O, Park S, Kim J, Lee H, Kim Y Int J Mol Sci. 2024; 25(14).

PMID: 39063213 PMC: 11277421. DOI: 10.3390/ijms25147971.

Advances in cardiac tissue engineering and heart-on-a-chip.

Kieda J, Shakeri A, Landau S, Wang E, Zhao Y, Lai B J Biomed Mater Res A. 2023; 112(4):492-511.

PMID: 37909362 PMC: 11213712. DOI: 10.1002/jbm.a.37633.

Ascorbic acid induces MLC2v protein expression and promotes ventricular-like cardiomyocyte subtype in human induced pluripotent stem cells derived cardiomyocytes.

Gao Y, Su L, Wei Y, Tan S, Hu Z, Tao Z Theranostics. 2023; 13(11):3872-3896.

PMID: 37441603 PMC: 10334833. DOI: 10.7150/thno.80801.

Precision medicine for long QT syndrome: patient-specific iPSCs take the lead.

Yu Y, Deschenes I, Zhao M Expert Rev Mol Med. 2023; 25:e5.

PMID: 36597672 PMC: 10302164. DOI: 10.1017/erm.2022.43.

References

Nebert D, Vesell E . Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics. Trends Pharmacol Sci. 2006; 27(11):580-6. DOI: 10.1016/j.tips.2006.09.008. View

Siramshetty V, Nickel J, Omieczynski C, Gohlke B, Drwal M, Preissner R . WITHDRAWN--a resource for withdrawn and discontinued drugs. Nucleic Acids Res. 2015; 44(D1):D1080-6. PMC: 4702851. DOI: 10.1093/nar/gkv1192. View

Paull D, Sevilla A, Zhou H, Hahn A, Kim H, Napolitano C . Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nat Methods. 2015; 12(9):885-92. DOI: 10.1038/nmeth.3507. View

Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A . Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J. 2011; 32(8):952-62. PMC: 3076668. DOI: 10.1093/eurheartj/ehr073. View

de Villiers C, van der Merwe L, Crotti L, Goosen A, George Jr A, Schwartz P . AKAP9 is a genetic modifier of congenital long-QT syndrome type 1. Circ Cardiovasc Genet. 2014; 7(5):599-606. PMC: 4270884. DOI: 10.1161/CIRCGENETICS.113.000580. View

Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni C, Veglia F . Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation. 2015; 131(22):1981-8. DOI: 10.1161/CIRCULATIONAHA.114.013777. View

Maillet A, Tan K, Chai X, Sadananda S, Mehta A, Ooi J . Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes. Sci Rep. 2016; 6:25333. PMC: 4855185. DOI: 10.1038/srep25333. View

Diaz G, Daniell K, Leitza S, Martin R, Su Z, McDermott J . The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o. J Pharmacol Toxicol Methods. 2004; 50(3):187-99. DOI: 10.1016/j.vascn.2004.04.001. View

Jones A, Edwards D, Cummins M, Williams A, George C . A Systemized Approach to Investigate Ca(2+) Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes. Front Cell Dev Biol. 2016; 3:89. PMC: 4710702. DOI: 10.3389/fcell.2015.00089. View

10.

Paci M, Hyttinen J, Rodriguez B, Severi S . Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block. Br J Pharmacol. 2015; 172(21):5147-60. PMC: 4629192. DOI: 10.1111/bph.13282. View

11.

Saric T, Halbach M, Khalil M, Er F . Induced pluripotent stem cells as cardiac arrhythmic in vitro models and the impact for drug discovery. Expert Opin Drug Discov. 2013; 9(1):55-76. DOI: 10.1517/17460441.2014.863275. View

12.

Schwach V, Passier R . Generation and purification of human stem cell-derived cardiomyocytes. Differentiation. 2016; 91(4-5):126-38. DOI: 10.1016/j.diff.2016.01.001. View

13.

Collins F, Varmus H . A new initiative on precision medicine. N Engl J Med. 2015; 372(9):793-5. PMC: 5101938. DOI: 10.1056/NEJMp1500523. View

14.

Fendyur A, Spira M . Toward on-chip, in-cell recordings from cultured cardiomyocytes by arrays of gold mushroom-shaped microelectrodes. Front Neuroeng. 2012; 5:21. PMC: 3426852. DOI: 10.3389/fneng.2012.00021. View

15.

McNaughton R, Huet G, Shakir S . An investigation into drug products withdrawn from the EU market between 2002 and 2011 for safety reasons and the evidence used to support the decision-making. BMJ Open. 2014; 4(1):e004221. PMC: 3902466. DOI: 10.1136/bmjopen-2013-004221. View

16.

Huebsch N, Loskill P, Mandegar M, Marks N, Sheehan A, Ma Z . Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. Tissue Eng Part C Methods. 2014; 21(5):467-79. PMC: 4410286. DOI: 10.1089/ten.TEC.2014.0283. View

17.

Zhang M, DAniello C, Verkerk A, Wrobel E, Frank S, Ward-van Oostwaard D . Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A. 2014; 111(50):E5383-92. PMC: 4273331. DOI: 10.1073/pnas.1419553111. View

18.

Mitcheson J, Hancox J, Levi A . Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties. Cardiovasc Res. 1998; 39(2):280-300. DOI: 10.1016/s0008-6363(98)00128-x. View

19.

Martignoni M, Groothuis G, de Kanter R . Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol. 2006; 2(6):875-94. DOI: 10.1517/17425255.2.6.875. View

20.

Altomare C, Bartolucci C, Sala L, Bernardi J, Mostacciuolo G, Rocchetti M . IKr Impact on Repolarization and Its Variability Assessed by Dynamic Clamp. Circ Arrhythm Electrophysiol. 2015; 8(5):1265-75. DOI: 10.1161/CIRCEP.114.002572. View