Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein

Overview

Journal Mol Cancer Res

Specialty Cell Biology

Date 2016 Sep 14

PMID 27621267

Citations 8

Authors

Antonia A Nemec

Korie B Bush

Jamie B Towle-Weicksel

B Frazier Taylor

Vincent Schulz

Joanne B Weidhaas

David P Tuck

Joann B Sweasy

Affiliations

Soon will be listed here.

Abstract

Implications: The Pol λ R438W mutation can serve as a biomarker to predict cancer risk and implicates that treatment with estrogen in individuals with this mutation may further increase their risk of breast cancer. Mol Cancer Res; 14(11); 1068-77. ©2016 AACR.

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