Sleep and Breathing … and Cancer?

Overview

Journal Cancer Prev Res (Phila)

Specialty Oncology

Date 2016 Sep 9

PMID 27604751

Citations 11

Authors

Robert L Owens

Kathryn A Gold

David Gozal

Paul E Peppard

Jonathan C Jun

Andrew J Dannenberg

Scott M Lippman

Atul Malhotra

Affiliations

Soon will be listed here.

Abstract

Sleep, like eating and breathing, is an essential part of the daily life cycle. Although the science is still emerging, sleep plays an important role in immune, cardiovascular, and neurocognitive function. Despite its great importance, nearly 40% of U.S. adults experience problems with sleep ranging from insufficient total sleep time, trouble initiating or maintaining sleep (Insomnia), circadian rhythm disorders, sleep-related movement disorders, and sleep-related breathing disorders such as obstructive sleep apnea (OSA). Herein, we discuss new evidence that suggests that sleep may also affect carcinogenesis. Specifically, we review recent epidemiologic data suggesting links between cancer and OSA. As OSA is a common, underdiagnosed, and undertreated condition, this has public health implications. Intriguing animal model data support a link between cancer and sleep/OSA, although mechanisms are not yet clear. Leaders in the fields of sleep medicine, pulmonology, and oncology recently met to review and discuss these data, as well as to outline future directions of study. We propose a multidisciplinary, three-pronged approach to studying the associations between cancer and sleep, utilizing mutually interactive epidemiologic studies, preclinical models, and early-phase clinical trials. Cancer Prev Res; 9(11); 821-7. ©2016 AACR.

Citing Articles

Obstructive sleep apnea severity, circulating biomarkers, and cancer risk.

Hirsch Allen A, Kendzerska T, Bhatti P, Jen R, Myers R, Hajipour M J Clin Sleep Med. 2024; 20(9):1415-1422.

PMID: 38648119 PMC: 11367715. DOI: 10.5664/jcsm.11170.

Circadian, hormonal, and sleep rhythms: effects on cancer progression implications for treatment.

Jagielo A, Benedict C, Spiegel D Front Oncol. 2023; 13:1269378.

PMID: 37746277 PMC: 10514358. DOI: 10.3389/fonc.2023.1269378.

Polysomnographic Assessment of Sleep Disturbances in Cancer Development: A Historical Multicenter Clinical Cohort Study.

Kendzerska T, Murray B, Gershon A, Povitz M, McIsaac D, Bryson G Chest. 2023; 164(2):517-530.

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Perceived Importance of Breast Cancer Risk Factors: A Survey on 386 Physicians in China.

Wing-Cheong Chow L, Fu P, Guo L, Hu X, Jiang J, Lie E Asian Pac J Cancer Prev. 2022; 23(2):379-382.

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Sleep apnea 20/20: a 20-year cohort that continues to inform the next 20 years.

Patel S, Combs D, Parthasarathy S J Clin Sleep Med. 2020; 16(S1):27-28.

PMID: 33054968 PMC: 7792887. DOI: 10.5664/jcsm.8894.

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