Hypoxia-inducible Factors: Key Regulators of Myeloid Cells During Inflammation

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2016 Sep 7

PMID 27599290

Citations 74

Authors

Nan Lin

M Celeste Simon

Affiliations

Soon will be listed here.

Abstract

Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and exerts significant influence on their progression. Macrophages and neutrophils are major cellular components of innate immunity and contribute not only to O2 deprivation at the site of inflammation, but also alter many of their functions in response to hypoxia to either facilitate or suppress inflammation. Hypoxia stabilizes HIF-αs in macrophages and neutrophils, and these O2-sensitive transcription factors are key regulators of inflammatory responses in myeloid cells. In this review, we will summarize our current understanding of the role of HIF-αs in shaping macrophage and neutrophil functions in the pathogenesis and progression of multiple inflammatory diseases.

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