Region-specific Roles of the Corticotropin-releasing Factor-urocortin System in Stress

Overview

Journal Nat Rev Neurosci

Specialty Neurology

Date 2016 Sep 3

PMID 27586075

Citations 101

Authors

Marloes J A G Henckens

Jan M Deussing

Alon Chen

Affiliations

Soon will be listed here.

Abstract

Dysregulation of the corticotropin-releasing factor (CRF)-urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed that CRF-CRF receptor type 1 (CRFR1) signalling promotes the stress response and anxiety-like behaviour, whereas UCNs and CRFR2 activation mediate stress recovery and the restoration of homeostasis. Recent findings, however, provide clear evidence that this view is overly simplistic. Instead, a more complex picture has emerged that suggests that there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.

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