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MicroRNAs in Allergic Disease

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Date 2016 Sep 3
PMID 27585977
Citations 25
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Abstract

Purpose Of Review: MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs that are increasingly being recognized as important epigenetic regulators. They have been implicated in the pathogenesis of many diseases including cancer, cardiovascular diseases, connective tissue diseases, and neuromuscular disorders.

Recent Findings: A few miRNAs have already been recognized as a core set of miRNAs important in allergic inflammation. These include let-7, miR-21, miR-142, and miR-146. This review aims to bring together some of the recent findings on how miRNAs regulate allergic inflammation with special focus on asthma, atopic dermatitis, allergic rhinitis, and eosinophilic esophagitis. We will also touch upon extracellular miRNAs and future perspective of this field of study.

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References
1.
Liacouras C, Furuta G, Hirano I, Atkins D, Attwood S, Bonis P . Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011; 128(1):3-20.e6. DOI: 10.1016/j.jaci.2011.02.040. View

2.
Sharma A, Kumar M, Ahmad T, Mabalirajan U, Aich J, Agrawal A . Antagonism of mmu-mir-106a attenuates asthma features in allergic murine model. J Appl Physiol (1985). 2012; 113(3):459-64. DOI: 10.1152/japplphysiol.00001.2012. View

3.
Zeng Y, Nguyen G, Jin H . MicroRNA-143 inhibits IL-13-induced dysregulation of the epidermal barrier-related proteins in skin keratinocytes via targeting to IL-13Rα1. Mol Cell Biochem. 2016; 416(1-2):63-70. DOI: 10.1007/s11010-016-2696-z. View

4.
Williams A, Larner-Svensson H, Perry M, Campbell G, Herrick S, Adcock I . MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One. 2009; 4(6):e5889. PMC: 2690402. DOI: 10.1371/journal.pone.0005889. View

5.
Lu T, Rothenberg M . Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. J Allergy Clin Immunol. 2013; 132(1):3-13. PMC: 3737592. DOI: 10.1016/j.jaci.2013.04.039. View