The Effect of Paf Antagonists on Bronchial Hyperresponsiveness Induced by Paf, Propranolol or Indomethacin

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1989 Jul 1

PMID 2758238

Citations 3

Authors

E J Dixon

P Wilsoncroft

D N Robertson

C P Page

Affiliations

Soon will be listed here.

Abstract

1. Intravenous administration of platelet activating factor, Paf (600 ng kg-1 h-1) to ventilated anaesthetised guinea-pigs induced bronchial hyperresponsiveness to i.v. acetylcholine. 2. Pretreatment of ventilated, anaesthetised guinea-pigs with the beta-adrenoceptor antagonist, propranolol, or the non-steroidal anti-inflammatory drug, indomethacin, induced bronchial hyperresponsiveness to i.v. histamine. 3. Paf-induced bronchial hyperresponsiveness was significantly attenuated by pretreatment with three different Paf antagonists, CV-3988, BN 52021 and WEB 2086. 4. Pretreatment of guinea-pigs with CV-3988, BN 52021 or WEB 2086 at doses inhibiting Paf-induced bronchial hyperresponsiveness, had no significant effect on propranolol or indomethacin-induced bronchial hyperresponsiveness. 5. It is suggested that bronchial hyperresponsiveness induced by propranolol or indomethacin is not secondary to Paf release in the guinea-pig.

Citing Articles

Increased airway reactivity in the guinea-pig follows exposure to intravenous isoprenaline.

Sanjar S, Kristersson A, Mazzoni L, Morley J, Schaeublin E J Physiol. 1990; 425:43-54.

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PAF. A review of its effects, antagonists and possible future clinical implications (Part II).

Koltai M, Hosford D, Guinot P, Esanu A, Braquet P Drugs. 1991; 42(2):174-204.

PMID: 1717219 DOI: 10.2165/00003495-199142020-00002.

The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils.

Miyagawa H, Nabe M, Hopp R, Okada C, Bewtra A, Townley G Agents Actions. 1992; 37(1-2):39-43.

PMID: 1456179 DOI: 10.1007/BF01987888.

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