Propolis: a New Frontier for Wound Healing?

Overview

Journal Burns Trauma

Publisher Oxford University Press

Date 2016 Aug 31

PMID 27574655

Citations 65

Authors

Simona Martinotti

Elia Ranzato

Affiliations

Soon will be listed here.

Abstract

Propolis is a resin produced by honeybees by mixing wax, pollen, salivary secretions, and collected natural resins. The precise composition of propolis varies with the source, and over 300 chemical components belonging to the flavonoids, terpenes, and phenolic acids have been identified in propolis. Moreover, its chemical composition is subjected to the geographical location, botanical origin, and bee species. Propolis and its compounds have been the focus of many works due to their antimicrobial and anti-inflammatory activity; however, it is now recognized that propolis also possesses regenerative properties. There is an increasing interest in the healing potential of natural products, considering the availability and low cost of these products. Propolis contains a huge number of compounds that explicate some biological effects that speeds up the healing process and is widely used in folk remedies. This review aims to condense the results on the mechanism of activity of propolis and its compounds.

Citing Articles

Propolis: A Natural Substance with Multifaceted Properties and Activities.

Martinotti S, Bonsignore G, Ranzato E Int J Mol Sci. 2025; 26(4).

PMID: 40003984 PMC: 11855500. DOI: 10.3390/ijms26041519.

Phenolic Content, Antioxidant Activity and In Vitro Anti-Inflammatory and Antitumor Potential of Selected Bulgarian Propolis Samples.

Tumbarski Y, Ivanov I, Todorova M, Apostolova S, Tzoneva R, Nikolova K Biomedicines. 2025; 13(2).

PMID: 40002747 PMC: 11852768. DOI: 10.3390/biomedicines13020334.

Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome.

Aldana-Mejia J, Pena Ribeiro V, Katragunta K, Avula B, Tatapudi K, Bastos J Plants (Basel). 2025; 13(24.

PMID: 39771273 PMC: 11677851. DOI: 10.3390/plants13243576.

Randomized Clinical Evaluation of the Healing Activity of Green Propolis Ointment in Individuals with Lower Limb Ulcers Resulting from Leprosy: Preliminary Results of a Pilot Study.

Rosa C, Maquedano L, Bueno I, Marson F, Longato G Pharmaceuticals (Basel). 2025; 17(12.

PMID: 39770464 PMC: 11679340. DOI: 10.3390/ph17121622.

An Overview of Wound Dressing Materials.

Lagoa T, Queiroga M, Martins L Pharmaceuticals (Basel). 2024; 17(9).

PMID: 39338274 PMC: 11434694. DOI: 10.3390/ph17091110.

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