Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2016 Aug 30

PMID 27569911

Citations 72

Authors

Yangnan Gu

Sophia G Zebell

Zizhen Liang

Shui Wang

Byung-Ho Kang

Xinnian Dong

Affiliations

Soon will be listed here.

Abstract

Nuclear transport of immune receptors, signal transducers, and transcription factors is an essential regulatory mechanism for immune activation. Whether and how this process is regulated at the level of the nuclear pore complex (NPC) remains unclear. Here, we report that CPR5, which plays a key inhibitory role in effector-triggered immunity (ETI) and programmed cell death (PCD) in plants, is a novel transmembrane nucleoporin. CPR5 associates with anchors of the NPC selective barrier to constrain nuclear access of signaling cargos and sequesters cyclin-dependent kinase inhibitors (CKIs) involved in ETI signal transduction. Upon activation by immunoreceptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for ETI signaling and reconfigures the selective barrier to allow significant influx of nuclear signaling cargos through the NPC. Consequently, these coordinated NPC actions result in simultaneous activation of diverse stress-related signaling pathways and constitute an essential regulatory mechanism specific for ETI/PCD induction.

Citing Articles

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