DNA-binding Studies of the Natural β-carboline Eudistomin U

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2016 Aug 28

PMID 27567367

Citations 6

Authors

Jennifer M Giulietti

Patrick M Tate

Ang Cai

Bongsup Cho

Seann P Mulcahy

Affiliations

Soon will be listed here.

Abstract

Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV-Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.

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