PICH Promotes Mitotic Chromosome Segregation: Identification of a Novel Role in RDNA Disjunction

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2016 Aug 28

PMID 27565185

Citations 20

Authors

Christian F Nielsen

Ian D Hickson

Affiliations

Soon will be listed here.

Abstract

PICH is an SNF2-family DNA translocase that appears to play a role specifically in mitosis. Characterization of PICH in human cells led to the initial discovery of "ultra-fine DNA bridges" (UFBs) that connect the 2 segregating DNA masses in the anaphase of mitosis. These bridge structures, which arise from specific regions of the genome, are a normal feature of anaphase but had escaped detection previously because they do not stain with commonly used DNA dyes. Nevertheless, UFBs are important for genome maintenance because defects in UFB resolution can lead to cytokinesis failure. We reported recently that PICH stimulates the unlinking (decatenation) of entangled DNA by Topoisomerase IIα (Topo IIα), and is important for the resolution of UFBs. We also demonstrated that PICH and Topo IIα co-localize at the rDNA (rDNA). In this Extra View article, we discuss the mitotic roles of PICH and explore further the role of PICH in the timely segregation of the rDNA locus.

Citing Articles

The interplay of the translocase activity and protein recruitment function of PICH in ultrafine anaphase bridge resolution and genomic stability.

Kong N, Chen K, Chanboonyasitt P, Jiang H, Wong K, Ma H Nucleic Acids Res. 2024; 53(3).

PMID: 39704103 PMC: 11797016. DOI: 10.1093/nar/gkae1249.

Human AAA+ ATPase FIGNL1 suppresses RAD51-mediated ultra-fine bridge formation.

Matsuzaki K, Shinohara A, Shinohara M Nucleic Acids Res. 2024; 52(10):5774-5791.

PMID: 38597669 PMC: 11162793. DOI: 10.1093/nar/gkae263.

PICH deficiency limits the progression of MYC-induced B-cell lymphoma.

Castejon-Grinan M, Albers E, Simon-Carrasco L, Aguilera P, Sbroggio M, Pladevall-Morera D Blood Cancer J. 2024; 14(1):16.

PMID: 38253636 PMC: 10803365. DOI: 10.1038/s41408-024-00979-y.

New Era of Mapping and Understanding Common Fragile Sites: An Updated Review on Origin of Chromosome Fragility.

Ji F, Zhu X, Liao H, Ouyang L, Huang Y, Syeda M Front Genet. 2022; 13:906957.

PMID: 35669181 PMC: 9164283. DOI: 10.3389/fgene.2022.906957.

The Abscission Checkpoint: A Guardian of Chromosomal Stability.

Petsalaki E, Zachos G Cells. 2021; 10(12).

PMID: 34943860 PMC: 8699595. DOI: 10.3390/cells10123350.

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