» Articles » PMID: 27561663

CD26 and Asthma: a Comprehensive Review

Overview
Date 2016 Aug 27
PMID 27561663
Citations 19
Authors
Affiliations
Soon will be listed here.
Abstract

Asthma is a heterogeneous and chronic inflammatory family of disorders of the airways with increasing prevalence that results in recurrent and reversible bronchial obstruction and expiratory airflow limitation. These diseases arise from the interaction between environmental and genetic factors, which collaborate to cause increased susceptibility and severity. Many asthma susceptibility genes are linked to the immune system or encode enzymes like metalloproteases (e.g., ADAM-33) or serine proteases. The S9 family of serine proteases (prolyl oligopeptidases) is capable to process peptide bonds adjacent to proline, a kind of cleavage-resistant peptide bonds present in many growth factors, chemokines or cytokines that are important for asthma. Curiously, two serine proteases within the S9 family encoded by genes located on chromosome 2 appear to have a role in asthma: CD26/dipeptidyl peptidase 4 (DPP4) and DPP10. The aim of this review is to summarize the current knowledge about CD26 and to provide a structured overview of the numerous functions and implications that this versatile enzyme could have in this disease, especially after the detection of some secondary effects (e.g., viral nasopharyngitis) in type II diabetes mellitus patients (a subset with a certain risk of developing obesity-related asthma) upon CD26 inhibitory therapy.

Citing Articles

Urinary Proteome and Exosome Analysis Protocol for the Discovery of Respiratory Diseases Biomarkers.

Martelo-Vidal L, Vazquez-Mera S, Miguens-Suarez P, Bravo-Lopez S, Makrinioti H, Dominguez-Arca V Biomolecules. 2025; 15(1).

PMID: 39858454 PMC: 11762655. DOI: 10.3390/biom15010060.


Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases.

Guo D, Liu Z, Zhou J, Ke C, Li D Int J Mol Sci. 2024; 25(18).

PMID: 39337436 PMC: 11432010. DOI: 10.3390/ijms25189947.


Development of the dipeptidyl peptidase 4 family and its association with lung diseases: a narrative review.

Hua E, Xu D, Chen H, Zhang S, Feng J, Xu L J Thorac Dis. 2024; 15(12):7024-7034.

PMID: 38249892 PMC: 10797411. DOI: 10.21037/jtd-23-1158.


Clinical and cytokine patterns of uncontrolled asthma with and without comorbid chronic rhinosinusitis: a cross-sectional study.

Huang K, Li F, Wang X, Yan B, Wang M, Li S Respir Res. 2022; 23(1):119.

PMID: 35546400 PMC: 9092818. DOI: 10.1186/s12931-022-02028-3.


The Roles of Dipeptidyl Peptidase 4 (DPP4) and DPP4 Inhibitors in Different Lung Diseases: New Evidence.

Zhang T, Tong X, Zhang S, Wang D, Wang L, Wang Q Front Pharmacol. 2021; 12:731453.

PMID: 34955820 PMC: 8696080. DOI: 10.3389/fphar.2021.731453.


References
1.
Bauvois B, De Meester I, Dumont J, Rouillard D, Zhao H, Bosmans E . Constitutive expression of CD26/dipeptidylpeptidase IV on peripheral blood B lymphocytes of patients with B chronic lymphocytic leukaemia. Br J Cancer. 1999; 79(7-8):1042-8. PMC: 2362248. DOI: 10.1038/sj.bjc.6690167. View

2.
Struyf S, Proost P, Schols D, De Clercq E, Opdenakker G, Lenaerts J . CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. J Immunol. 1999; 162(8):4903-9. View

3.
van der Velden V, Hulsmann A . Peptidases: structure, function and modulation of peptide-mediated effects in the human lung. Clin Exp Allergy. 1999; 29(4):445-56. PMC: 7162142. DOI: 10.1046/j.1365-2222.1999.00462.x. View

4.
Iwata S, Yamaguchi N, Munakata Y, Ikushima H, Lee J, Hosono O . CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response. Int Immunol. 1999; 11(3):417-26. DOI: 10.1093/intimm/11.3.417. View

5.
van der Velden V, Naber B, van Hal P, Overbeek S, Hoogsteden H, Versnel M . Peptidase activities in serum and bronchoalveolar lavage fluid from allergic asthmatics--comparison with healthy non-smokers and smokers and effects of inhaled glucocorticoids. Clin Exp Allergy. 1999; 29(6):813-23. DOI: 10.1046/j.1365-2222.1999.00550.x. View