The Pharmacology of Palmitoylethanolamide and First Data on the Therapeutic Efficacy of Some of Its New Formulations

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2016 Aug 20

PMID 27539936

Citations 159

Authors

Stefania Petrosino

Vincenzo Di Marzo

Affiliations

Soon will be listed here.

Abstract

Linked Articles: This article is part of a themed section on Principles of Pharmacological Research of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc.

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References

Di Marzo V, De Petrocellis L . Endocannabinoids as regulators of transient receptor potential (TRP) channels: A further opportunity to develop new endocannabinoid-based therapeutic drugs. Curr Med Chem. 2010; 17(14):1430-49. DOI: 10.2174/092986710790980078. View

Gatti A, Lazzari M, Gianfelice V, Di Paolo A, Sabato E, Sabato A . Palmitoylethanolamide in the treatment of chronic pain caused by different etiopathogenesis. Pain Med. 2012; 13(9):1121-30. DOI: 10.1111/j.1526-4637.2012.01432.x. View

Conti S, Costa B, Colleoni M, Parolaro D, Giagnoni G . Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. Br J Pharmacol. 2002; 135(1):181-7. PMC: 1573125. DOI: 10.1038/sj.bjp.0704466. View

Cerrato S, Brazis P, Della Valle M, Miolo A, Puigdemont A . Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells. Vet Immunol Immunopathol. 2009; 133(1):9-15. DOI: 10.1016/j.vetimm.2009.06.011. View

Starowicz K, Cristino L, Di Marzo V . TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications. Curr Pharm Des. 2008; 14(1):42-54. DOI: 10.2174/138161208783330790. View

Schreiber D, Harlfinger S, Nolden B, Gerth C, Jaehde U, Schomig E . Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. Anal Biochem. 2007; 361(2):162-8. DOI: 10.1016/j.ab.2006.11.027. View

Giuffrida A, Piomelli D . Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma. FEBS Lett. 1998; 422(3):373-6. DOI: 10.1016/s0014-5793(98)00046-5. View

Levi-Montalcini R, Skaper S, Dal Toso R, Petrelli L, Leon A . Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci. 1996; 19(11):514-20. DOI: 10.1016/S0166-2236(96)10058-8. View

Farquhar-Smith W, Rice A . Administration of endocannabinoids prevents a referred hyperalgesia associated with inflammation of the urinary bladder. Anesthesiology. 2001; 94(3):507-13; discussion 6A. DOI: 10.1097/00000542-200103000-00023. View

10.

Esposito E, Cuzzocrea S . Palmitoylethanolamide in homeostatic and traumatic central nervous system injuries. CNS Neurol Disord Drug Targets. 2013; 12(1):55-61. DOI: 10.2174/1871527311312010010. View

11.

Andresen S, Bing J, Hansen R, Biering-Sorensen F, Johannesen I, Hagen E . Ultramicronized palmitoylethanolamide in spinal cord injury neuropathic pain: a randomized, double-blind, placebo-controlled trial. Pain. 2016; 157(9):2097-2103. DOI: 10.1097/j.pain.0000000000000623. View

12.

Abramo F, Campora L, Albanese F, Della Valle M, Cristino L, Petrosino S . Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis. BMC Vet Res. 2014; 10:21. PMC: 3923739. DOI: 10.1186/1746-6148-10-21. View

13.

Costa B, Conti S, Giagnoni G, Colleoni M . Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems. Br J Pharmacol. 2002; 137(4):413-20. PMC: 1573522. DOI: 10.1038/sj.bjp.0704900. View

14.

Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S . Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc Natl Acad Sci U S A. 2009; 106(49):20966-71. PMC: 2791595. DOI: 10.1073/pnas.0907417106. View

15.

Zygmunt P, Petersson J, Andersson D, Chuang H, Sorgard M, Di Marzo V . Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. 1999; 400(6743):452-7. DOI: 10.1038/22761. View

16.

Campora L, Miragliotta V, Ricci E, Cristino L, Di Marzo V, Albanese F . Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis. Am J Vet Res. 2012; 73(7):988-95. DOI: 10.2460/ajvr.73.7.988. View

17.

Zhukov O . [Distribution of N-([1-14C]-palmitoyl)ethanolamine in rat tissues]. Ukr Biokhim Zh (1999). 2000; 71(4):124-5. View

18.

Schabitz W, Giuffrida A, Berger C, Aschoff A, Schwaninger M, Schwab S . Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. Stroke. 2002; 33(8):2112-4. DOI: 10.1161/01.str.0000023491.63693.18. View

19.

Bettoni I, Comelli F, Colombo A, Bonfanti P, Costa B . Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide. CNS Neurol Disord Drug Targets. 2013; 12(1):34-44. DOI: 10.2174/1871527311312010008. View

20.

Loverme J, Russo R, La Rana G, Fu J, Farthing J, Mattace-Raso G . Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha. J Pharmacol Exp Ther. 2006; 319(3):1051-61. DOI: 10.1124/jpet.106.111385. View