The Case for Live Attenuated Vaccines Against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis

Overview

Journal PLoS Negl Trop Dis

Specialties Infectious Diseases
Tropical Medicine

Date 2016 Aug 19

PMID 27537413

Citations 13

Authors

Aseem Pandey

Ana Cabello

Lavoisier Akoolo

Allison Rice-Ficht

Angela Arenas-Gamboa

David McMurray

Thomas A Ficht

Paul de Figueiredo

Affiliations

Soon will be listed here.

Abstract

Vaccination of humans and animals with live attenuated organisms has proven to be an effective means of combatting some important infectious diseases. In fact, the 20th century witnessed tremendous improvements in human and animal health worldwide as a consequence of large-scale vaccination programs with live attenuated vaccines (LAVs). Here, we use the neglected zoonotic diseases brucellosis and bovine tuberculosis (BTb) caused by Brucella spp. and Mycobacterium bovis (M. bovis), respectively, as comparative models to outline the merits of LAV platforms with emphasis on molecular strategies that have been pursued to generate LAVs with enhanced vaccine safety and efficacy profiles. Finally, we discuss the prospects of LAV platforms in the fight against brucellosis and BTb and outline new avenues for future research towards developing effective vaccines using LAV platforms.

Citing Articles

Comparative longitudinal analysis of T lymphocyte subpopulations in calves vaccinated with different doses of BCG-Phipps or with culture filtrate protein extract of Mycobacterium bovis in a natural transmission setting.

Diaz-Otero F, Jaramillo-Meza L, Manzo-Sandoval A, Olguin-Alor R, Diosdado-Vargas F BMC Vet Res. 2025; 21(1):78.

PMID: 39972321 PMC: 11837346. DOI: 10.1186/s12917-025-04572-8.

One-step preparation of a self-assembled bioconjugate nanovaccine against .

Huang J, Guo Y, Yu S, Wang D, Li S, Wu J Virulence. 2023; 14(1):2280377.

PMID: 37981707 PMC: 10732601. DOI: 10.1080/21505594.2023.2280377.

Engineering live attenuated vaccines: Old dogs learning new tricks.

Plocica J, Guo F, Das J, Kobayashi K, Ficht T, Alaniz R J Transl Autoimmun. 2023; 6:100198.

PMID: 37090898 PMC: 10113845. DOI: 10.1016/j.jtauto.2023.100198.

KbvR mutant of Klebsiella pneumoniae affects the synthesis of type 1 fimbriae and provides protection to mice as a live attenuated vaccine.

Zhang F, Meng Y, Xu L, Tian Y, Lu H, Xie J Vet Res. 2022; 53(1):97.

PMID: 36435858 PMC: 9701397. DOI: 10.1186/s13567-022-01116-y.

A Brucella melitensis H38ΔwbkF rough mutant protects against Brucella ovis in rams.

Munoz P, Conde-Alvarez R, Andres-Barranco S, de Miguel M, Zuniga-Ripa A, Aragon-Aranda B Vet Res. 2022; 53(1):16.

PMID: 35236406 PMC: 8889640. DOI: 10.1186/s13567-022-01034-z.

References

van der Walt M, Greeff A . The production of an auxotrophic marked, plasmid-cured Salmonella ser. Typhimurium as a live attenuated vaccine. Onderstepoort J Vet Res. 1998; 65(3):213-20. View

Hesseling A, Rabie H, Marais B, Manders M, Lips M, Schaaf H . Bacille Calmette-Guérin vaccine-induced disease in HIV-infected and HIV-uninfected children. Clin Infect Dis. 2006; 42(4):548-58. DOI: 10.1086/499953. View

Koskiniemi S, Sun S, Berg O, Andersson D . Selection-driven gene loss in bacteria. PLoS Genet. 2012; 8(6):e1002787. PMC: 3386194. DOI: 10.1371/journal.pgen.1002787. View

Lacerda T, Cardoso P, de Almeida L, Camargo I, Afonso D, Trant C . Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in mice. Vaccine. 2010; 28(34):5627-34. DOI: 10.1016/j.vaccine.2010.06.023. View

Kim S, Lee D, Watanabe K, Furuoka H, Suzuki H, Watarai M . Interferon-gamma promotes abortion due to Brucella infection in pregnant mice. BMC Microbiol. 2005; 5:22. PMC: 1090583. DOI: 10.1186/1471-2180-5-22. View

Wang Z, Wu Q . Research progress in live attenuated Brucella vaccine development. Curr Pharm Biotechnol. 2013; 14(10):887-96. DOI: 10.2174/1389201014666131226123016. View

Lopez-Valencia G, Renteria-Evangelista T, Williams J, Licea-Navarro A, Mora-Valle A, Medina-Basulto G . Field evaluation of the protective efficacy of Mycobacterium bovis BCG vaccine against bovine tuberculosis. Res Vet Sci. 2009; 88(1):44-9. DOI: 10.1016/j.rvsc.2009.05.022. View

Jiang W, Bikard D, Cox D, Zhang F, Marraffini L . RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol. 2013; 31(3):233-9. PMC: 3748948. DOI: 10.1038/nbt.2508. View

Poester F, Goncalves V, Paixao T, Santos R, Olsen S, Schurig G . Efficacy of strain RB51 vaccine in heifers against experimental brucellosis. Vaccine. 2006; 24(25):5327-34. DOI: 10.1016/j.vaccine.2006.04.020. View

10.

Rajasekaran P, Surendran N, Seleem M, Sriranganathan N, Schurig G, Boyle S . Over-expression of homologous antigens in a leucine auxotroph of Brucella abortus strain RB51 protects mice against a virulent B. suis challenge. Vaccine. 2011; 29(17):3106-10. DOI: 10.1016/j.vaccine.2011.02.054. View

11.

Koh K, Lehming N, Seah G . Degradation-resistant protein domains limit host cell processing and immune detection of mycobacteria. Mol Immunol. 2009; 46(7):1312-8. DOI: 10.1016/j.molimm.2008.11.008. View

12.

Bianco M, Clark S, Blanco F, Garbaccio S, Garcia E, Cataldi A . Assessment of Mycobacterium bovis deleted in p27-p55 virulence operon as candidate vaccine against tuberculosis in animal models. Biomed Res Int. 2014; 2014:951978. PMC: 3918748. DOI: 10.1155/2014/951978. View

13.

Goel D, Bhatnagar R . Intradermal immunization with outer membrane protein 25 protects Balb/c mice from virulent B. abortus 544. Mol Immunol. 2012; 51(2):159-68. DOI: 10.1016/j.molimm.2012.02.126. View

14.

Islam M, Khatun M, Werre S, Sriranganathan N, Boyle S . A review of Brucella seroprevalence among humans and animals in Bangladesh with special emphasis on epidemiology, risk factors and control opportunities. Vet Microbiol. 2013; 166(3-4):317-26. DOI: 10.1016/j.vetmic.2013.06.014. View

15.

Wright P, Kervina M, Thompson J, Torrence A, Karzon D . Live attenuated influenza vaccines in young seronegative children. Dev Biol Stand. 1977; 39:99-103. View

16.

Davis D, Templeton J, Ficht T, Huber J, Angus R, Adams L . Brucella abortus in Bison. II. Evaluation of strain 19 vaccination of pregnant cows. J Wildl Dis. 1991; 27(2):258-64. DOI: 10.7589/0090-3558-27.2.258. View

17.

Munoz P, de Miguel M, Grillo M, Marin C, Barberan M, Blasco J . Immunopathological responses and kinetics of Brucella melitensis Rev 1 infection after subcutaneous or conjunctival vaccination in rams. Vaccine. 2008; 26(21):2562-9. DOI: 10.1016/j.vaccine.2008.03.030. View

18.

McDermott J, Arimi S . Brucellosis in sub-Saharan Africa: epidemiology, control and impact. Vet Microbiol. 2002; 90(1-4):111-34. DOI: 10.1016/s0378-1135(02)00249-3. View

19.

Parlane N, Shu D, Subharat S, Wedlock D, Rehm B, de Lisle G . Revaccination of cattle with bacille Calmette-Guérin two years after first vaccination when immunity has waned, boosted protection against challenge with Mycobacterium bovis. PLoS One. 2014; 9(9):e106519. PMC: 4152303. DOI: 10.1371/journal.pone.0106519. View

20.

Kalpana G, Bloom B, Jacobs Jr W . Insertional mutagenesis and illegitimate recombination in mycobacteria. Proc Natl Acad Sci U S A. 1991; 88(12):5433-7. PMC: 51887. DOI: 10.1073/pnas.88.12.5433. View