Long Term Neurotoxicity of Styrene. A Quantitative Study of Glial Fibrillary Acidic Protein (GFA) and S-100

Overview

Journal Br J Ind Med

Specialty Occupational Medicine

Date 1989 May 1

PMID 2751929

Citations 4

Authors

L E Rosengren

K G Haglid

Affiliations

Soon will be listed here.

Abstract

Little information exists about the possible neurotoxicity of styrene. The present study was designed to explore whether long term inhalation exposure (three months) to styrene (90 and 320 ppm) could induce long lasting astroglial alterations in Sprague Dawley rats, traceable four months after exposure ceased. Styrene exposure at 320 ppm induced such alterations as shown by raised concentrations of the glial cell marker, glial fibrillary acidic protein (GFA) in the sensory motor cortex and in the hippocampus. GFA is the structural protein of the astroglial filaments and formation of these filaments has been shown after damage to the central nervous system from any cause. It is concluded that exposure to styrene at moderate exposure levels induces regional, long lasting astroglial reactions that serve as an indicator of solvent induced brain damage.

Citing Articles

Environmental styrene exposure and neurologic symptoms in U.S. Gulf coast residents.

Werder E, Engel L, Richardson D, Emch M, Gerr F, Kwok R Environ Int. 2018; 121(Pt 1):480-490.

PMID: 30278311 PMC: 6712572. DOI: 10.1016/j.envint.2018.09.025.

Biomarker research in neurotoxicology: the role of mechanistic studies to bridge the gap between the laboratory and epidemiological investigations.

Costa L Environ Health Perspect. 1996; 104 Suppl 1:55-67.

PMID: 8722110 PMC: 1469567. DOI: 10.1289/ehp.96104s155.

Quantitative alterations of S-100 protein and neuron specific enolase in the rat nervous system after chronic 2,5-hexanedione exposure.

Karlsson J, Wang S, Rosengren L, Haglid K Neurochem Res. 1993; 18(2):203-8.

PMID: 8474562 DOI: 10.1007/BF01474685.

Dose dependent effects of chronic exposure to toluene on neuronal and glial cell marker proteins in the central nervous system of rats.

Huang J, Asaeda N, Takeuchi Y, Shibata E, Hisanaga N, Ono Y Br J Ind Med. 1992; 49(4):282-6.

PMID: 1571298 PMC: 1012111. DOI: 10.1136/oem.49.4.282.

References

Rosengren L, Kjellstrand P, Aurell A, Haglid K . Irreversible effects of dichloromethane on the brain after long term exposure: a quantitative study of DNA and the glial cell marker proteins S-100 and GFA. Br J Ind Med. 1986; 43(5):291-9. PMC: 1007652. DOI: 10.1136/oem.43.5.291. View

Rosengren L, Kjellstrand P, Haglid K . Tetrachloroethylene: levels of DNA and S-100 in the gerbil CNS after chronic exposure. Neurobehav Toxicol Teratol. 1986; 8(2):201-6. View

Romanelli A, FALZOI M, Mutti A, Bergamaschi E, Franchini I . Effects of some monocyclic aromatic solvents and their metabolites on brain dopamine in rabbits. J Appl Toxicol. 1986; 6(6):431-6. DOI: 10.1002/jat.2550060609. View

Rosengren L, Kjellstrand P, Aurell A, Haglid K . Irreversible effects of xylene on the brain after long term exposure: a quantitative study of DNA and the glial cell marker proteins S-100 and GFA. Neurotoxicology. 1986; 7(3):121-35. View

Brock T, OCallaghan J . Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocyte-specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system. J Neurosci. 1987; 7(4):931-42. PMC: 6569013. View

Stavrou D, Lubbe I, Haglid K . [Immunoelectrophoretic quantitation of the brain specific S-100 protein (author's transl)]. Acta Neuropathol. 1974; 29(3):275-80. DOI: 10.1007/BF00685263. View

Seppalainen A, Harkonen H . Neurophysiological findings among workers occupationally exposed to styrene. Scand J Work Environ Health. 1976; 2(3):140-6. DOI: 10.5271/sjweh.2810. View

Miyakawa T, Hattori E, Shikai I, Shimoji A, Nagatoshi K . Histopathological changes of chronic alcoholism. Folia Psychiatr Neurol Jpn. 1977; 31(2):253-61. DOI: 10.1111/j.1440-1819.1977.tb02726.x. View

LILIS R, Lorimer W, Diamond S, SELIKOFF I . Neurotoxicity of styrene in production and polymerization workers. Environ Res. 1978; 15(1):133-8. DOI: 10.1016/0013-9351(78)90086-5. View

10.

Rosen I, HAEGER-ARONSEN B, Rehnstrom S, Welinder H . Neurophysiological observations after chronic styrene exposure. Scand J Work Environ Health. 1978; 4 Suppl 2:184-94. View

11.

Lorimer W, LILIS R, Fischbein A, Daum S, Anderson H, Wolff M . Health status of styrene-polystyrene polymerization workers. Scand J Work Environ Health. 1978; 4 Suppl 2:220-6. View

12.

Marietta M, Vesell E, Hartman R, Weisz J, Dvorchik B . Characterization of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain: comparison with hepatic aminopyrine N-demethylation. J Pharmacol Exp Ther. 1979; 208(2):271-9. View

13.

BARROWCLIFF D, Knell A . Cerebral damage due to endogenous chronic carbon monoxide poisoning caused by exposure to methylene chloride. J Soc Occup Med. 1979; 29(1):12-4. DOI: 10.1093/occmed/29.1.12. View

14.

Latov N, Nilaver G, Zimmerman E, Johnson W, Silverman A, Defendini R . Fibrillary astrocytes proliferate in response to brain injury: a study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine. Dev Biol. 1979; 72(2):381-4. DOI: 10.1016/0012-1606(79)90127-1. View

15.

Rueger D, Huston J, Dahl D, Bignami A . Formation of 100 A filaments from purified glial fibrillary acidic protein in vitro. J Mol Biol. 1979; 135(1):53-68. DOI: 10.1016/0022-2836(79)90340-1. View

16.

Haglid K, Kjellstrand P, Rosengren L, Wronski A, Briving C . Effects of trichloroethylene inhalation on proteins of the gerbil brain. Arch Toxicol. 1980; 43(3):187-99. DOI: 10.1007/BF00297584. View

17.

Cherry N, Waldron H, Wells G, WILKINSON R, Wilson H, Jones S . An investigation of the acute behavioural effects of styrene on factory workers. Br J Ind Med. 1980; 37(3):234-40. PMC: 1008701. DOI: 10.1136/oem.37.3.234. View

18.

Amaducci L, Forno K, Eng L . Glial fibrillary acidic protein in cryogenic lesions of the rat brain. Neurosci Lett. 1981; 21(1):27-32. DOI: 10.1016/0304-3940(81)90052-5. View

19.

Barrett C, Guth L, DONATI E, Krikorian J . Astroglial reaction in the gray matter lumbar segments after midthoracic transection of the adult rat spinal cord. Exp Neurol. 1981; 73(2):365-77. DOI: 10.1016/0014-4886(81)90272-7. View

20.

Bruhn P, Arlien-Soborg P, Gyldensted C, Christensen E . Prognosis in chronic toxic encephalopathy. A two-year follow-up study in 26 house painters with occupational encephalopathy. Acta Neurol Scand. 1981; 64(4):259-72. View