Prognostic Value of Long Non-coding RNA UCA1 in Human Solid Tumors

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Aug 13

PMID 27517147

Citations 10

Authors

Fang-Teng Liu

Pei-Qian Zhu

Hong-Liang Luo

Yi Zhang

Cheng Qiu

Affiliations

Soon will be listed here.

Abstract

Background: Numerous studies have shown that the expression of UCA1 was aberrantly upregulated in various cancer types. High expression of UCA1 was reported to be associated with unfavorable prognosis in cancer patients.

Results: A total of 1240 patients from 15 articles were included. The results indicated that a significantly shorter OS was observed in patients with high expression level of UCA1 (HR = 1.71, 95% CI: 1.43-1.99), in the subgroup analysis, the association was also observed in patients with cancers of digestive system (HR = 2.12, 95% CI: 1.59-2.66). Statistical significance was also observed in subgroup meta-analysis stratified by the cancer type, cut-off value, analysis type and sample size. Furthermore, poorer DFS was observed in patients with high expression level of UCA1 (HR = 2.54; 95% CI: 1.09-4.00). Additionally, the pooled odds ratios (ORs) showed that increased UCA1 was also related to positive lymph node metastasis (OR = 2.98, 95% CI: 2.06-4.30), distant metastasis (OR = 3.14, 95% CI: 1.77-5.58) and poor clinical stage (OR = 2.76, 95% CI: 2.08-3.68).

Materials And Methods: A comprehensive retrieval was conducted in multiple databases, including PubMed, Embase, Web of Science and CNKI. We collected relevant articles to explore the association between the expression levels of UCA1 and prognosis.

Conclusions: High expression level of UCA1 was associated with poor clinical outcome. UCA1 could serve as a novel biomarker for prognosis and might be a potential predictive factor for clinicopathological characteristics in various cancers. Further studies should be performed to verify the clinical utility of UCA1 in human solid tumors.

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References

Ni B, Yu X, Guo X, Fan X, Yang Z, Wu P . Increased urothelial cancer associated 1 is associated with tumor proliferation and metastasis and predicts poor prognosis in colorectal cancer. Int J Oncol. 2015; 47(4):1329-38. DOI: 10.3892/ijo.2015.3109. View

Yang C, Li X, Wang Y, Zhao L, Chen W . Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene. 2012; 496(1):8-16. DOI: 10.1016/j.gene.2012.01.012. View

Na X, Liu Z, Ren P, Yu R, Shang X . Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway. Int J Clin Exp Med. 2015; 8(8):12609-16. PMC: 4612857. View

Dhamija S, Diederichs S . From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis. Int J Cancer. 2016; 139(2):269-80. DOI: 10.1002/ijc.30039. View

Xue M, Pang H, Li X, Li H, Pan J, Chen W . Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway. Cancer Sci. 2015; 107(1):18-27. PMC: 4724815. DOI: 10.1111/cas.12844. View

Tian Y, Zhang X, Hao Y, Fang Z, He Y . Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma. Melanoma Res. 2014; 24(4):335-41. DOI: 10.1097/CMR.0000000000000080. View

Colombo T, Farina L, Macino G, Paci P . PVT1: a rising star among oncogenic long noncoding RNAs. Biomed Res Int. 2015; 2015:304208. PMC: 4391155. DOI: 10.1155/2015/304208. View

Li J, Ma X, Zhang C . Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2015; 7(11):7938-44. PMC: 4270573. View

Yamashita A, Shichino Y, Yamamoto M . The long non-coding RNA world in yeasts. Biochim Biophys Acta. 2015; 1859(1):147-54. DOI: 10.1016/j.bbagrm.2015.08.003. View

10.

Shang C, Guo Y, Zhang J, Huang B . Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer. Cancer Chemother Pharmacol. 2016; 77(5):1061-7. DOI: 10.1007/s00280-016-3029-3. View

11.

Wang H, Lu J, Chen W, Gu A . Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma. Int J Clin Exp Med. 2015; 8(7):11824-30. PMC: 4565407. View

12.

Wu W, Zhang S, Li X, Xue M, Cao S, Chen W . Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. PLoS One. 2013; 8(9):e73920. PMC: 3771932. DOI: 10.1371/journal.pone.0073920. View

13.

Chen S, Shao C, Xu M, Ji J, Xie Y, Lei Y . Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1. Int J Clin Exp Pathol. 2015; 8(8):9052-61. PMC: 4583879. View

14.

Li H, Li X, Pang H, Pan J, Xie X, Chen W . Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer. Jpn J Clin Oncol. 2015; 45(11):1055-63. DOI: 10.1093/jjco/hyv132. View

15.

Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F . Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J. 2014; 281(7):1750-8. DOI: 10.1111/febs.12737. View

16.

Wang X, Zhang Z, Wang H, Cai J, Xu Q, Li M . Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res. 2006; 12(16):4851-8. DOI: 10.1158/1078-0432.CCR-06-0134. View

17.

Wang F, Zhou J, Xie X, Hu J, Chen L, Hu Q . Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells. Neoplasma. 2015; 62(3):432-8. View

18.

Tao K, Yang J, Hu Y, Sun Y, Tan Z, Duan J . Clinical significance of urothelial carcinoma associated 1 in colon cancer. Int J Clin Exp Med. 2016; 8(11):21854-60. PMC: 4724001. View

19.

Yang Y, Jiang Y, Wan Y, Zhang L, Qiu J, Zhou S . UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis. Tumour Biol. 2016; 37(8):10633-41. DOI: 10.1007/s13277-016-4917-1. View

20.

Huang J, Zhou N, Watabe K, Lu Z, Wu F, Xu M . Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis. 2014; 5:e1008. PMC: 4040676. DOI: 10.1038/cddis.2013.541. View