Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma

Overview

Journal Oncologist

Publisher Oxford University Press

Specialty Oncology

Date 2016 Aug 12

PMID 27511905

Citations 57

Authors

Mario E Lacouture

Brigitte Dreno

Paolo Antonio Ascierto

Reinhard Dummer

Nicole Basset-Seguin

Kate Fife

Scott Ernst

Lisa Licitra

Rogerio I Neves

Ketty Peris

Susana Puig

Jonas Sokolof

Aleksandar Sekulic

Axel Hauschild

Rainer Kunstfeld

Affiliations

Soon will be listed here.

Abstract

Implications For Practice: The hedgehog pathway inhibitors (HPIs) vismodegib and sonidegib represent a therapeutic breakthrough for patients with advanced basal cell carcinoma. However, the nature of the low-grade adverse events (AEs) commonly observed in HPI-treated patients, including muscle spasms, ageusia/dysgeusia, alopecia, weight loss, and fatigue, can impact clinical outcomes as a result of decreased quality of life and treatment discontinuation. The incidence, clinical presentation, putative mechanisms, and management strategies for AEs related to administration of HPIs are described, with the goal of enabling health care professionals to provide appropriate counseling and supportive care interventions to their patients.

Citing Articles

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S2k guideline basal cell carcinoma of the skin (update 2023).

Lang B, Balermpas P, Bauer A, Blum A, Dirschka T, Follmann M J Dtsch Dermatol Ges. 2024; 22(12):1697-1714.

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Gorlin Syndrome-Associated Basal Cell Carcinomas Treated with Vismodegib or Sonidegib: A Retrospective Study.

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