Epidermal Growth Factor Gene is a Newly Identified Candidate Gene for Gout

Overview

Journal Sci Rep

Specialty Science

Date 2016 Aug 11

PMID 27506295

Citations 2

Authors

Lin Han

Chunwei Cao

Zhaotong Jia

Shiguo Liu

Zhen Liu

Ruosai Xin

Can Wang

Xinde Li

Wei Ren

Xuefeng Wang

Changgui Li

Affiliations

Soon will be listed here.

Abstract

Chromosome 4q25 has been identified as a genomic region associated with gout. However, the associations of gout with the genes in this region have not yet been confirmed. Here, we performed two-stage analysis to determine whether variations in candidate genes in the 4q25 region are associated with gout in a male Chinese Han population. We first evaluated 96 tag single nucleotide polymorphisms (SNPs) in eight inflammatory/immune pathway- or glucose/lipid metabolism-related genes in the 4q25 region in 480 male gout patients and 480 controls. The SNP rs12504538, located in the elongation of very-long-chain-fatty-acid-like family member 6 gene (Elovl6), was found to be associated with gout susceptibility (Padjusted = 0.00595). In the second stage of analysis, we performed fine mapping analysis of 93 tag SNPs in Elovl6 and in the epidermal growth factor gene (EGF) and its flanking regions in 1017 male patients gout and 1897 healthy male controls. We observed a significant association between the T allele of EGF rs2298999 and gout (odds ratio = 0.77, 95% confidence interval = 0.67-0.88, Padjusted = 6.42 × 10(-3)). These results provide the first evidence for an association between the EGF rs2298999 C/T polymorphism and gout. Our findings should be validated in additional populations.

Citing Articles

Causal relationship between inflammatory proteins, immune cells, and gout: a Mendelian randomization study.

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Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.

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