Expression of CD1a by Langerhan's Cells in Oral Lichen Planus - A Retrospective Analysis

Overview

Journal J Clin Diagn Res

Specialty General Medicine

Date 2016 Aug 10

PMID 27504405

Citations 6

Authors

Ganesh Kulkarni

Esther Priyadarshini Sakki

Yennavaram Vijay Kumar

Sadananda Kolimi

Ravi Perika

Kalepu Venkata Karthik

Kandukuri Mahesh Kumar

Venumbaka Siva Kalyan

Affiliations

Soon will be listed here.

Abstract

Introduction: Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen.

Aim: The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium.

Materials And Methods: A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test.

Results: LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001).

Conclusion: The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.

Citing Articles

MAIT cells modulating the oral lichen planus immune microenvironment: a cellular crosstalk perspective.

Mi Q, Wu X, Chen Y, Meng W Inflamm Res. 2025; 74(1):10.

PMID: 39762617 DOI: 10.1007/s00011-024-01990-6.

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system.

Kim S, Cho S, Kim J Exp Mol Med. 2023; 55(9):1858-1871.

PMID: 37696897 PMC: 10545705. DOI: 10.1038/s12276-023-01053-6.

Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia.

Dafar A, Siarov A, Mostaghimi Y, Robledo-Sierra J, De Lara S, Giglio D Int J Dent. 2022; 2022:5430309.

PMID: 35360707 PMC: 8964229. DOI: 10.1155/2022/5430309.

Oral lichen planus: a microbiologist point of view.

Villa T, Sanchez-Perez A, Sieiro C Int Microbiol. 2021; 24(3):275-289.

PMID: 33751292 PMC: 7943413. DOI: 10.1007/s10123-021-00168-y.

Marking vertebrates langerhans cells, from fish to mammals.

Alesci A, Lauriano E, Aragona M, Capillo G, Pergolizzi S Acta Histochem. 2020; 122(7):151622.

PMID: 33066843 PMC: 7480233. DOI: 10.1016/j.acthis.2020.151622.

References

Bramanti T, Dekker N, Lozada-Nur F, Sauk J, Regezi J . Heat shock (stress) proteins and gamma delta T lymphocytes in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 80(6):698-704. DOI: 10.1016/s1079-2104(05)80254-9. View

Sugerman P, Savage N, Walsh L, Zhao Z, Zhou X, Khan A . The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med. 2002; 13(4):350-65. DOI: 10.1177/154411130201300405. View

Scully C, Beyli M, Ferreiro M, Ficarra G, Gill Y, Griffiths M . Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med. 1998; 9(1):86-122. DOI: 10.1177/10454411980090010501. View

van Loon L, Krieg S, Davidson C, Bos J . Quantification and distribution of lymphocyte subsets and Langerhans cells in normal human oral mucosa and skin. J Oral Pathol Med. 1989; 18(4):197-201. DOI: 10.1111/j.1600-0714.1989.tb00762.x. View

Gueiros L, Gondak R, Jorge Junior J, Coletta R, de Albuquerque Carvalho A, Leao J . Increased number of Langerhans cells in oral lichen planus and oral lichenoid lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 113(5):661-6. DOI: 10.1016/j.oooo.2011.12.008. View

Chou L, Epstein J, Cassol S, West D, He W, Firth J . Oral mucosal Langerhans' cells as target, effector and vector in HIV infection. J Oral Pathol Med. 2000; 29(8):394-402. DOI: 10.1034/j.1600-0714.2000.290805.x. View

Santoro A, Majorana A, Roversi L, Gentili F, Marrelli S, Vermi W . Recruitment of dendritic cells in oral lichen planus. J Pathol. 2005; 205(4):426-34. DOI: 10.1002/path.1699. View

Mizumoto N, Takashima A . CD1a and langerin: acting as more than Langerhans cell markers. J Clin Invest. 2004; 113(5):658-60. PMC: 351325. DOI: 10.1172/JCI21140. View

Mukae S, Okazaki Y, Tsuda H, Nagai K, Matsumoto N, Ochiai T . Detection of fascin and CCR-7 positive mature dendritic cells in oral lichen planus. J Oral Pathol Med. 2009; 38(4):334-42. DOI: 10.1111/j.1600-0714.2008.00741.x. View

10.

Upadhyay J, Upadhyay R, Agrawal P, Jaitley S, Shekhar R . Langerhans cells and their role in oral mucosal diseases. N Am J Med Sci. 2013; 5(9):505-14. PMC: 3818822. DOI: 10.4103/1947-2714.118923. View

11.

Villarroel Dorrego M, Correnti M, Delgado R, Tapia F . Oral lichen planus: immunohistology of mucosal lesions. J Oral Pathol Med. 2002; 31(7):410-4. DOI: 10.1034/j.1600-0714.2002.00097.x. View

12.

Chou M, Daniels T . Langerhans cells expressing HLA-DQ, HLA-DR and T6 antigens in normal oral mucosa and lichen planus. J Oral Pathol Med. 1989; 18(10):573-6. DOI: 10.1111/j.1600-0714.1989.tb01554.x. View

13.

Gustafson J, Eklund C, Wallstrom M, Zellin G, Magnusson B, Hasseus B . Langerin-expressing and CD83-expressing cells in oral lichen planus lesions. Acta Odontol Scand. 2007; 65(3):156-61. DOI: 10.1080/00016350601137251. View

14.

Roopashree M, Gondhalekar R, Shashikanth M, George J, Thippeswamy S, Shukla A . Pathogenesis of oral lichen planus--a review. J Oral Pathol Med. 2010; 39(10):729-34. DOI: 10.1111/j.1600-0714.2010.00946.x. View

15.

Lombardi T, Hauser C, Budtz-Jorgensen E . Langerhans cells: structure, function and role in oral pathological conditions. J Oral Pathol Med. 1993; 22(5):193-202. DOI: 10.1111/j.1600-0714.1993.tb01056.x. View

16.

Lo Muzio L, Mignogna M, Favia G, Procaccini M, Testa N, Bucci E . The possible association between oral lichen planus and oral squamous cell carcinoma: a clinical evaluation on 14 cases and a review of the literature. Oral Oncol. 1998; 34(4):239-46. DOI: 10.1016/s1368-8375(98)00001-3. View

17.

Eisenberg E . Oral lichen planus: a benign lesion. J Oral Maxillofac Surg. 2000; 58(11):1278-85. DOI: 10.1053/joms.2000.16629. View

18.

Eversole L, Dam J, Ficarra G, Hwang C . Leukocyte adhesion molecules in oral lichen planus: a T cell-mediated immunopathologic process. Oral Microbiol Immunol. 1994; 9(6):376-83. DOI: 10.1111/j.1399-302x.1994.tb00289.x. View

19.

Farthing P, Matear P, Cruchley A . The activation of Langerhans cells in oral lichen planus. J Oral Pathol Med. 1990; 19(2):81-5. DOI: 10.1111/j.1600-0714.1990.tb00801.x. View

20.

Sloberg K, Jonsson R, Jontell M . Assessment of Langerhans' cells in oral lichen planus using monoclonal antibodies. J Oral Pathol. 1984; 13(5):516-24. DOI: 10.1111/j.1600-0714.1984.tb01452.x. View