Langerhans Cells and Their Role in Oral Mucosal Diseases

Overview

Journal N Am J Med Sci

Specialty General Medicine

Date 2013 Nov 20

PMID 24251267

Citations 21

Authors

Juhi Upadhyay

Ram B Upadhyay

Pankaj Agrawal

Shweta Jaitley

Rhitu Shekhar

Affiliations

Soon will be listed here.

Abstract

Dendritic cells are arguably the most potent antigen-presenting cells and may be the only cells capable of initiating the adaptive immune response. The epithelial residents of dendritic cells are Langerhans cells, which serve as the "sentinels" of the mucosa, altering the immune system not only to pathogen entry but also of tolerance to self antigen and commensal microbes. Oral mucosal Langerhans cells are capable of engaging and internalizing a wide variety of pathogens and have been found responsive to nickel in patients with nickel allergies, oral Candida species, oral lichen planus, lichenoid drug eruptions, graft versus host diseases, periodontal diseases median rhomboid glossitis, human immunodeficiency virus infection, hairy leukoplakia of the tongue, and oral squamous cell carcinoma. Review focuses on the role of antigen-presenting cells in particular Langerhans cells to better understand the mechanisms underlying immune responses. In this review, comprehensive detail about mucosal diseases has been compiled using the PubMed database and through textbooks.

Citing Articles

Periodontitis Continuum: Antecedents, Triggers, Mediators, and Treatment Strategies.

Benahmed A, Tippairote T, Gasmi A, Noor S, Avdeev O, Shanaida Y Curr Med Chem. 2024; 31(41):6775-6800.

PMID: 39428847 DOI: 10.2174/0109298673265862231020051338.

The oral-gut-circulatory axis: from homeostasis to colon cancer.

Tortora S, Gonzalez Agurto M, Martello L Front Cell Infect Microbiol. 2023; 13:1289452.

PMID: 38029267 PMC: 10663299. DOI: 10.3389/fcimb.2023.1289452.

CD83 Regulates the Immune Responses in Inflammatory Disorders.

Riaz B, Islam S, Ryu H, Sohn S Int J Mol Sci. 2023; 24(3).

PMID: 36769151 PMC: 9917562. DOI: 10.3390/ijms24032831.

Immune response differences in degradable and non-degradable alloy implants.

Khodaei T, Schmitzer E, Suresh A, Acharya A Bioact Mater. 2023; 24:153-170.

PMID: 36606252 PMC: 9793227. DOI: 10.1016/j.bioactmat.2022.12.012.

Profile and Potential Significance of Dendritic Cells in Head and Neck Squamous Cell Carcinoma.

Dumitru C, Ceausu A, Gaje N, Raica M Cancer Diagn Progn. 2022; 2(6):758-763.

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