Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2016 Aug 3

PMID 27481466

Citations 124

Authors

Kimberly A Dowd

Christina R DeMaso

Rebecca S Pelc

Scott D Speer

Alexander R Y Smith

Leslie Goo

Derek J Platt

John R Mascola

Barney S Graham

Mark J Mulligan

Michael S Diamond

Julie E Ledgerwood

Theodore C Pierson

Affiliations

Soon will be listed here.

Abstract

Recent epidemics of Zika virus (ZIKV) have been associated with congenital malformation during pregnancy and Guillain-Barré syndrome. There are two ZIKV lineages (African and Asian) that share >95% amino acid identity. Little is known regarding the ability of neutralizing antibodies elicited against one lineage to protect against the other. We investigated the breadth of the neutralizing antibody response following ZIKV infection by measuring the sensitivity of six ZIKV strains to neutralization by ZIKV-confirmed convalescent human serum or plasma samples. Contemporary Asian and early African ZIKV strains were similarly sensitive to neutralization regardless of the cellular source of virus. Furthermore, mouse immune serum generated after infection with African or Asian ZIKV strains was capable of neutralizing homologous and heterologous ZIKV strains equivalently. Because our study only defines a single ZIKV serotype, vaccine candidates eliciting robust neutralizing antibody responses should inhibit infection of both ZIKV lineages, including strains circulating in the Americas.

Citing Articles

pr-independent biogenesis of infectious mature Zika virus particles.

Dowd K, Schroeder M, Sanchez E, Brumbaugh B, Foreman B, Burgomaster K bioRxiv. 2024; .

PMID: 39372759 PMC: 11452192. DOI: 10.1101/2024.09.12.612520.

Simultaneous quantitation of neutralizing antibodies against all four dengue virus serotypes using optimized reporter virus particles.

Lingemann M, Amaro-Carambot E, Lamirande E, Pierson T, Whitehead S J Virol. 2024; 98(7):e0068124.

PMID: 38953379 PMC: 11265411. DOI: 10.1128/jvi.00681-24.

Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies.

Contreras M, Stuart J, Levoir L, Belmont L, Goo L mBio. 2024; 15(2):e0304823.

PMID: 38193697 PMC: 10865826. DOI: 10.1128/mbio.03048-23.

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies.

Kikawa C, Cartwright-Acar C, Stuart J, Contreras M, Levoir L, Evans M J Virol. 2023; 97(11):e0141423.

PMID: 37943046 PMC: 10688354. DOI: 10.1128/jvi.01414-23.

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.

Lubow J, Levoir L, Ralph D, Belmont L, Contreras M, Cartwright-Acar C PLoS Pathog. 2023; 19(10):e1011722.

PMID: 37812640 PMC: 10586629. DOI: 10.1371/journal.ppat.1011722.

References

Hazin A, Poretti A, Cruz D, Tenorio M, van der Linden A, Pena L . Computed Tomographic Findings in Microcephaly Associated with Zika Virus. N Engl J Med. 2016; 374(22):2193-5. DOI: 10.1056/NEJMc1603617. View

Katzelnick L, Fonville J, Gromowski G, Bustos Arriaga J, Green A, James S . Dengue viruses cluster antigenically but not as discrete serotypes. Science. 2015; 349(6254):1338-43. PMC: 4876809. DOI: 10.1126/science.aac5017. View

Brasil P, Carvalho Sequeira P, dAvila Freitas A, Zogbi H, Amaral Calvet G, de Souza R . Guillain-Barré syndrome associated with Zika virus infection. Lancet. 2016; 387(10026):1482. DOI: 10.1016/S0140-6736(16)30058-7. View

Guy B, Lang J, Saville M, Jackson N . Vaccination Against Dengue: Challenges and Current Developments. Annu Rev Med. 2015; 67:387-404. DOI: 10.1146/annurev-med-091014-090848. View

Brasil P, Amaral Calvet G, Siqueira A, Wakimoto M, de Sequeira P, Nobre A . Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects. PLoS Negl Trop Dis. 2016; 10(4):e0004636. PMC: 4829157. DOI: 10.1371/journal.pntd.0004636. View

Cao-Lormeau V, Blake A, Mons S, Lastere S, Roche C, Vanhomwegen J . Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet. 2016; 387(10027):1531-1539. PMC: 5444521. DOI: 10.1016/S0140-6736(16)00562-6. View

Burton D . Antibodies, viruses and vaccines. Nat Rev Immunol. 2002; 2(9):706-13. DOI: 10.1038/nri891. View

Shrestha B, Brien J, Sukupolvi-Petty S, Austin S, Edeling M, Kim T . The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1. PLoS Pathog. 2010; 6(4):e1000823. PMC: 2848552. DOI: 10.1371/journal.ppat.1000823. View

Rossi S, Tesh R, Azar S, Muruato A, Hanley K, Auguste A . Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg. 2016; 94(6):1362-1369. PMC: 4889758. DOI: 10.4269/ajtmh.16-0111. View

10.

Mason R, TAURASO N, SPERTZEL R, Ginn R . Yellow fever vaccine: direct challenge of monkeys given graded doses of 17D vaccine. Appl Microbiol. 1973; 25(4):539-44. PMC: 380857. DOI: 10.1128/am.25.4.539-544.1973. View

11.

Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F . Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro Surveill. 2014; 19(9). DOI: 10.2807/1560-7917.es2014.19.9.20720. View

12.

Kuhn R, Dowd K, Post C, Pierson T . Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host. Virology. 2015; 479-480:508-17. PMC: 4900690. DOI: 10.1016/j.virol.2015.03.025. View

13.

Pierson T, Diamond M . A game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infection. Prog Mol Biol Transl Sci. 2015; 129:141-66. PMC: 4910618. DOI: 10.1016/bs.pmbts.2014.10.005. View

14.

Pierson T, Xu Q, Nelson S, Oliphant T, Nybakken G, Fremont D . The stoichiometry of antibody-mediated neutralization and enhancement of West Nile virus infection. Cell Host Microbe. 2007; 1(2):135-45. PMC: 2656919. DOI: 10.1016/j.chom.2007.03.002. View

15.

Lazear H, Govero J, Smith A, Platt D, Fernandez E, Miner J . A Mouse Model of Zika Virus Pathogenesis. Cell Host Microbe. 2016; 19(5):720-30. PMC: 4866885. DOI: 10.1016/j.chom.2016.03.010. View

16.

Dick G . Epidemiological notes on some viruses isolated in Uganda; Yellow fever, Rift Valley fever, Bwamba fever, West Nile, Mengo, Semliki forest, Bunyamwera, Ntaya, Uganda S and Zika viruses. Trans R Soc Trop Med Hyg. 1953; 47(1):13-48. DOI: 10.1016/0035-9203(53)90021-2. View

17.

Dai L, Song J, Lu X, Deng Y, Musyoki A, Cheng H . Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody. Cell Host Microbe. 2016; 19(5):696-704. DOI: 10.1016/j.chom.2016.04.013. View

18.

VanBlargan L, Mukherjee S, Dowd K, Durbin A, Whitehead S, Pierson T . The type-specific neutralizing antibody response elicited by a dengue vaccine candidate is focused on two amino acids of the envelope protein. PLoS Pathog. 2013; 9(12):e1003761. PMC: 3857832. DOI: 10.1371/journal.ppat.1003761. View

19.

Mukherjee S, Dowd K, Manhart C, Ledgerwood J, Durbin A, Whitehead S . Mechanism and significance of cell type-dependent neutralization of flaviviruses. J Virol. 2014; 88(13):7210-20. PMC: 4054442. DOI: 10.1128/JVI.03690-13. View

20.

Baronti C, Piorkowski G, Charrel R, Boubis L, Leparc-Goffart I, de Lamballerie X . Complete coding sequence of zika virus from a French polynesia outbreak in 2013. Genome Announc. 2014; 2(3). PMC: 4047448. DOI: 10.1128/genomeA.00500-14. View