MiRNA-regulated Cancer Stem Cells: Understanding the Property and the Role of MiRNA in Carcinogenesis

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 Jul 30

PMID 27468722

Citations 35

Authors

Chiranjib Chakraborty

Kok-Yong Chin

Srijit Das

Affiliations

Soon will be listed here.

Abstract

Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.

Citing Articles

MicroRNA-21 as a Regulator of Cancer Stem Cell Properties in Oral Cancer.

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The Role of miR-486-5p on CSCs Phenotypes in Colorectal Cancer.

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miRNA on the Battlefield of Cancer: Significance in Cancer Stem Cells, WNT Pathway, and Treatment.

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Salivary micro RNAs as biomarkers for oropharyngeal cancer.

Weeramange C, Tang K, Barrero R, Hartel G, Liu Z, Ladwa R Cancer Med. 2023; 12(14):15128-15140.

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