Liposomal Prednisolone Inhibits Vascular Inflammation and Enhances Venous Outward Remodeling in a Murine Arteriovenous Fistula Model

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jul 28

PMID 27460883

Citations 21

Authors

ChunYu Wong

Taisiya Bezhaeva

Tonia C Rothuizen

Josbert M Metselaar

Margreet R de Vries

Floris P R Verbeek

Alexander L Vahrmeijer

Anouk Wezel

Anton-Jan van Zonneveld

Ton J Rabelink

Paul H A Quax

Joris I Rotmans

Affiliations

Soon will be listed here.

Abstract

Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulate in the post-anastomotic area of the venous outflow tract in which the vascular pathology is most prominent in failed AVFs. On a histological level, we observed a reduction of lymphocytes and granulocytes in the vascular wall. In addition, a strong anti-inflammatory effect of liposomal prednisolone on macrophages was demonstrated in vitro. Therefore, treatment with liposomal prednisolone might be a valuable strategy to improve AVF maturation.

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