Dynamic Phosphorylation of Histone Deacetylase 1 by Aurora Kinases During Mitosis Regulates Zebrafish Embryos Development

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jul 27

PMID 27458029

Citations 6

Authors

Sara Loponte

Chiara V Segre

Silvia Senese

Claudia Miccolo

Stefano Santaguida

Gianluca Deflorian

Simona Citro

Domenico Mattoscio

Federica Pisati

Mirjam A Moser

Rosella Visintin

Christian Seiser

Susanna Chiocca

Affiliations

Soon will be listed here.

Abstract

Histone deacetylases (HDACs) catalyze the removal of acetyl molecules from histone and non-histone substrates playing important roles in chromatin remodeling and control of gene expression. Class I HDAC1 is a critical regulator of cell cycle progression, cellular proliferation and differentiation during development; it is also regulated by many post-translational modifications (PTMs). Herein we characterize a new mitosis-specific phosphorylation of HDAC1 driven by Aurora kinases A and B. We show that this phosphorylation affects HDAC1 enzymatic activity and it is critical for the maintenance of a proper proliferative and developmental plan in a complex organism. Notably, we find that Aurora-dependent phosphorylation of HDAC1 regulates histone acetylation by modulating the expression of genes directly involved in the developing zebrafish central nervous system. Our data represent a step towards the comprehension of HDAC1 regulation by its PTM code, with important implications in unravelling its roles both in physiology and pathology.

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