Social Adversity and Psychosis: The Mediating Role of Cognitive Vulnerability

Overview

Journal Schizophr Bull

Publisher Oxford University Press

Specialty Psychiatry

Date 2016 Jul 25

PMID 27451429

Citations 15

Authors

Edo S Jaya

Leonie Ascone

Tania M Lincoln

Affiliations

Soon will be listed here.

Abstract

Background: Social adversity is a risk factor for psychosis, but the translating mechanisms are not well understood. This study tests whether the relationship between social adversity and psychosis is mediated by cognitive vulnerability in the form of low perceived social rank, negative schemas related to self and other, and loneliness and whether the putative mediations are specific to psychosis or are largely explained by depression.

Methods: The study was a survey in a community sample (N = 2350) from Germany (n = 786), Indonesia (n = 844), and the United States (n = 720). Mediation path analysis with structural equation modeling was used to test for the specificity of the hypothesized paths to psychosis controlling for depression.

Results: Social adversity had a significant medium to large effect on positive (R2 = .20) and negative symptoms (R2 = .38). Social rank, negative schemas, and loneliness significantly mediated the relationship between social adversity and negative symptoms and the models explained a large amount of the variance (R2 = .43-.44). For positive symptoms, only negative schemas were a significant mediator (R2 = .27).

Discussion: The results emphasize the role of social adversity in psychosis and support the assumption that cognitive vulnerability is a relevant translating mechanism as postulated by the social defeat hypothesis and cognitive models of psychosis. This underlines the relevance of the clinical practice of targeting beliefs in cognitive interventions for psychosis. It also indicates that targeting cognitive vulnerability in people experiencing social adversity could be a promising approach to prevention.

Citing Articles

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Recent social stress and severity of auditory hallucinations.

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Psychosocial stress, interpersonal sensitivity, and social withdrawal in clinical high risk for psychosis: a systematic review.

Georgiades A, Almuqrin A, Rubinic P, Mouhitzadeh K, Tognin S, Mechelli A Schizophrenia (Heidelb). 2023; 9(1):38.

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Paranoid Thinking as a Function of Minority Group Status and Intersectionality: An International Examination of the Role of Negative Beliefs.

Kingston J, Schlier B, Lincoln T, So S, Gaudiano B, Morris E Schizophr Bull. 2023; 49(4):1078-1087.

PMID: 36940411 PMC: 10318883. DOI: 10.1093/schbul/sbad027.

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