Senicapoc: a Potent Candidate for the Treatment of a Subset of Hereditary Xerocytosis Caused by Mutations in the Gardos Channel

Overview

Journal Haematologica

Specialty Hematology

Date 2016 Jul 23

PMID 27443288

Citations 20

Authors

Raphael Rapetti-Mauss

Olivier Soriani

Henri Vinti

Catherine Badens

Helene Guizouarn

Affiliations

Soon will be listed here.

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References

Garneau L, Klein H, Banderali U, Longpra-Lauzon A, Parent L, Sauva R . Hydrophobic interactions as key determinants to the KCa3.1 channel closed configuration. An analysis of KCa3.1 mutants constitutively active in zero Ca2+. J Biol Chem. 2008; 284(1):389-403. DOI: 10.1074/jbc.M805700200. View

Glogowska E, Gallagher P . Disorders of erythrocyte volume homeostasis. Int J Lab Hematol. 2015; 37 Suppl 1:85-91. PMC: 4435826. DOI: 10.1111/ijlh.12357. View

Wiley J, McCulloch K . Calcium ions, drug action and the red cell membrane. Pharmacol Ther. 1982; 18(2):271-92. DOI: 10.1016/0163-7258(82)90070-5. View

Ataga K, Smith W, De Castro L, Swerdlow P, Saunthararajah Y, Castro O . Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia. Blood. 2008; 111(8):3991-7. DOI: 10.1182/blood-2007-08-110098. View

Andolfo I, Russo R, Manna F, Shmukler B, Gambale A, Vitiello G . Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis). Am J Hematol. 2015; 90(10):921-6. DOI: 10.1002/ajh.24117. View

Rapetti-Mauss R, Lacoste C, Picard V, Guitton C, Lombard E, Loosveld M . A mutation in the Gardos channel is associated with hereditary xerocytosis. Blood. 2015; 126(11):1273-80. DOI: 10.1182/blood-2015-04-642496. View

Glogowska E, Lezon-Geyda K, Maksimova Y, Schulz V, Gallagher P . Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis. Blood. 2015; 126(11):1281-4. PMC: 4566808. DOI: 10.1182/blood-2015-07-657957. View

Maher A, Kuchel P . The Gárdos channel: a review of the Ca2+-activated K+ channel in human erythrocytes. Int J Biochem Cell Biol. 2003; 35(8):1182-97. DOI: 10.1016/s1357-2725(02)00310-2. View

Zarychanski R, Schulz V, Houston B, Maksimova Y, Houston D, Smith B . Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012; 120(9):1908-15. PMC: 3448561. DOI: 10.1182/blood-2012-04-422253. View

10.

Bennekou P, Harbak H, Simonsen L . Vanadate-induced Ca(2+) and Co(2+) uptake in human red blood cells. Blood Cells Mol Dis. 2011; 48(2):102-9. DOI: 10.1016/j.bcmd.2011.11.002. View

11.

Garneau L, Klein H, Parent L, Sauve R . Toward the rational design of constitutively active KCa3.1 mutant channels. Methods Enzymol. 2010; 485:437-57. DOI: 10.1016/B978-0-12-381296-4.00024-5. View

12.

Stocker J, De Franceschi L, McNaughton-Smith G, Corrocher R, Beuzard Y, Brugnara C . ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2002; 101(6):2412-8. DOI: 10.1182/blood-2002-05-1433. View

13.

Wulff H, Gutman G, Cahalan M, Chandy K . Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001; 276(34):32040-5. DOI: 10.1074/jbc.M105231200. View

14.

Ataga K, Reid M, Ballas S, Yasin Z, Bigelow C, James L . Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker.... Br J Haematol. 2011; 153(1):92-104. DOI: 10.1111/j.1365-2141.2010.08520.x. View

15.

Brugnara C, De Franceschi L, Alper S . Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest. 1993; 92(1):520-6. PMC: 293641. DOI: 10.1172/JCI116597. View