Methicillin-Resistant Staphylococcus Aureus Recovered from Healthcare- and Community-Associated Infections in Egypt

Overview

Journal Int J Bacteriol

Date 2016 Jul 20

PMID 27433480

Citations 18

Authors

Mohamed Abdel-Maksoud

Mona El-Shokry

Ghada Ismail

Soad Hafez

Amani El-Kholy

Ehab Attia

Maha Talaat

Affiliations

Soon will be listed here.

Abstract

Background. Methicillin-resistant Staphylococcus aureus (MRSA) has created significant epidemiological, infection-control, and therapeutic management challenges during the past three decades. Aim. To analyze the pattern of resistance of healthcare- and community-associated MRSA in Egypt and the trend of resistance of HA-MRSA over time (2005-2013). Methods. MRSA isolates were recovered from healthcare-associated (HA) and community-associated (CA) Staphylococcus aureus (S. aureus) infections. They were tested against 11 antimicrobial discs and the minimal inhibitory concentration (MIC) of vancomycin was determined. Inducible clindamycin resistance (iMLSB) was also screened using D-test. Findings. Of 631 S. aureus, MRSA was identified in 343 (76.6%) and 21 (11.5%) of HA and CA S. aureus isolates, respectively. The proportion of HA-MRSA increased significantly from 48.6% in 2005 to 86.8% in 2013 (p value < 0.001). Multidrug resistance (MDR) was observed in 85.8% of HA-MRSA and 48.6% of CA-MRSA. Vancomycin intermediate resistant S. aureus (VISA) was detected in 1.2% of HA-MRSA and none was detected in CA-MRSA. Among HA-MRSA strains, 5.3% showed iMLSB compared to 9.5% among CA-MRSA. Conclusion. The upsurge of the prevalence rates of HA-MRSA over time is alarming and urges for an effective infection control strategy and continuous monitoring of antimicrobial use.

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References

P R V, M J . A comparative analysis of community acquired and hospital acquired methicillin resistant Staphylococcus aureus. J Clin Diagn Res. 2013; 7(7):1339-42. PMC: 3749631. DOI: 10.7860/JCDR/2013/5302.3139. View

Falagas M, Karageorgopoulos D, Leptidis J, Korbila I . MRSA in Africa: filling the global map of antimicrobial resistance. PLoS One. 2013; 8(7):e68024. PMC: 3726677. DOI: 10.1371/journal.pone.0068024. View

Baddour M, Abuelkheir M, J Fatani A . Trends in antibiotic susceptibility patterns and epidemiology of MRSA isolates from several hospitals in Riyadh, Saudi Arabia. Ann Clin Microbiol Antimicrob. 2006; 5:30. PMC: 1713249. DOI: 10.1186/1476-0711-5-30. View

Ahmed S, Daef E, Badary M, Mahmoud M, Abd-Elsayed A . Nosocomial blood stream infection in intensive care units at Assiut University Hospitals (Upper Egypt) with special reference to extended spectrum beta-lactamase producing organisms. BMC Res Notes. 2009; 2:76. PMC: 2694819. DOI: 10.1186/1756-0500-2-76. View

Hiramatsu K, Hanaki H, Ino T, YABUTA K, Oguri T, Tenover F . Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother. 1997; 40(1):135-6. DOI: 10.1093/jac/40.1.135. View

Ghenghesh K, Rahouma A, Tawil K, Zorgani A, Franka E . Antimicrobial resistance in Libya: 1970-2011. Libyan J Med. 2013; 8(1):20567. PMC: 3610430. DOI: 10.3402/ljm.v8i0.20567. View

Patel M, Waites K, Moser S, Cloud G, Hoesley C . Prevalence of inducible clindamycin resistance among community- and hospital-associated Staphylococcus aureus isolates. J Clin Microbiol. 2006; 44(7):2481-4. PMC: 1489468. DOI: 10.1128/JCM.02582-05. View

Borg M, de Kraker M, Scicluna E, van de Sande-Bruinsma N, Tiemersma E, Monen J . Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in invasive isolates from southern and eastern Mediterranean countries. J Antimicrob Chemother. 2007; 60(6):1310-5. DOI: 10.1093/jac/dkm365. View

Chowers M, Paitan Y, Gottesman B, Gerber B, Ben-Nissan Y, Shitrit P . Hospital-wide methicillin-resistant Staphylococcus aureus control program: A 5-year follow-up. Infect Control Hosp Epidemiol. 2009; 30(8):778-81. DOI: 10.1086/599019. View

10.

Hadler J, Petit S, Mandour M, Cartter M . Trends in invasive infection with methicillin-resistant Staphylococcus aureus, Connecticut, USA, 2001-2010. Emerg Infect Dis. 2012; 18(6):917-24. PMC: 3358174. DOI: 10.3201/eid1806.120182. View

11.

Sabry N, Farid S, Dawoud D . Antibiotic dispensing in Egyptian community pharmacies: an observational study. Res Social Adm Pharm. 2013; 10(1):168-84. DOI: 10.1016/j.sapharm.2013.03.004. View

12.

Hanaki H, Cui L, Ikeda-Dantsuji Y, Nakae T, Honda J, Yanagihara K . Antibiotic susceptibility survey of blood-borne MRSA isolates in Japan from 2008 through 2011. J Infect Chemother. 2014; 20(9):527-34. DOI: 10.1016/j.jiac.2014.06.012. View

13.

Cimolai N . Methicillin-resistant Staphylococcus aureus in Canada: a historical perspective and lessons learned. Can J Microbiol. 2010; 56(2):89-120. DOI: 10.1139/w09-109. View

14.

Kandeel A, El-Shoubary W, Hicks L, Fattah M, Dooling K, Lohiniva A . Patient Attitudes and Beliefs and Provider Practices Regarding Antibiotic Use for Acute Respiratory Tract Infections in Minya, Egypt. Antibiotics (Basel). 2016; 3(4):632-44. PMC: 4790377. DOI: 10.3390/antibiotics3040632. View

15.

Lall M, Sahni A . Prevalence of inducible clindamycin resistance in Staphylococcus aureus isolated from clinical samples. Med J Armed Forces India. 2014; 70(1):43-7. PMC: 3946413. DOI: 10.1016/j.mjafi.2013.01.004. View

16.

Thati V, Shivannavar C, Gaddad S . Vancomycin resistance among methicillin resistant Staphylococcus aureus isolates from intensive care units of tertiary care hospitals in Hyderabad. Indian J Med Res. 2011; 134(5):704-8. PMC: 3249970. DOI: 10.4103/0971-5916.91001. View

17.

Chavez-Bueno S, Bozdogan B, Katz K, Bowlware K, Cushion N, Cavuoti D . Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas. Antimicrob Agents Chemother. 2005; 49(6):2283-8. PMC: 1140519. DOI: 10.1128/AAC.49.6.2283-2288.2005. View

18.

Huang H, Flynn N, King J, Monchaud C, Morita M, Cohen S . Comparisons of community-associated methicillin-resistant Staphylococcus aureus (MRSA) and hospital-associated MSRA infections in Sacramento, California. J Clin Microbiol. 2006; 44(7):2423-7. PMC: 1489486. DOI: 10.1128/JCM.00254-06. View

19.

Araj G, Kanj S . Current status and changing trends of antimicrobial resistance in Lebanon. J Med Liban. 2001; 48(4):221-6. View

20.

Kholy A, Baseem H, Hall G, Procop G, Longworth D . Antimicrobial resistance in Cairo, Egypt 1999-2000: a survey of five hospitals. J Antimicrob Chemother. 2003; 51(3):625-30. DOI: 10.1093/jac/dkg101. View