Prevalence of Inducible Clindamycin Resistance Among Community- and Hospital-associated Staphylococcus Aureus Isolates

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2006 Jul 11

PMID 16825368

Citations 39

Authors

Mukesh Patel

Ken B Waites

Stephen A Moser

Gretchen A Cloud

Craig J Hoesley

Affiliations

Soon will be listed here.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infections have become common among both hospitalized and nonhospitalized patients. Optimal outpatient therapy for MRSA infections has yet to be determined, but this matter is complicated by the possibility of inducible macrolide-lincosamide-streptogramin B resistance (MLSBi). We studied the prevalence of MLSBi in community- and hospital-associated S. aureus isolates and the prevalence of community-associated MRSA (CA-MRSA) and identified clinical predictors of CA-MRSA and MLSBi. Among 402 S. aureus isolates, the overall prevalence of MLSBi was 52%, with 50% of MRSA and 60% of methicillin-susceptible S. aureus isolates exhibiting MLSBi. CA-MRSA represented 14% of all isolates and had a lower prevalence of MLSBi than hospital-associated MRSA (33% versus 55%). The presence of skin or soft-tissue infection was predictive for CA-MRSA, and the presence of a comorbidity was predictive for MLSBi. Due to the low prevalence of MLSBi among CA-MRSA isolates, clindamycin remains a useful option for outpatient therapy.

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References

Rao G . Should clindamycin be used in treatment of patients with infections caused by erythromycin-resistant staphylococci?. J Antimicrob Chemother. 2000; 45(5):715. DOI: 10.1093/jac/45.5.715. View

Chavez-Bueno S, Bozdogan B, Katz K, Bowlware K, Cushion N, Cavuoti D . Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas. Antimicrob Agents Chemother. 2005; 49(6):2283-8. PMC: 1140519. DOI: 10.1128/AAC.49.6.2283-2288.2005. View

Ma X, Ito T, Tiensasitorn C, Jamklang M, Chongtrakool P, Boyle-Vavra S . Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother. 2002; 46(4):1147-52. PMC: 127097. DOI: 10.1128/AAC.46.4.1147-1152.2002. View

Frank A, Marcinak J, Mangat P, Tjhio J, Kelkar S, Schreckenberger P . Clindamycin treatment of methicillin-resistant Staphylococcus aureus infections in children. Pediatr Infect Dis J. 2002; 21(6):530-4. DOI: 10.1097/00006454-200206000-00010. View

Dufour P, Gillet Y, Bes M, Lina G, Vandenesch F, Floret D . Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin Infect Dis. 2002; 35(7):819-24. DOI: 10.1086/342576. View

Sattler C, Mason Jr E, Kaplan S . Prospective comparison of risk factors and demographic and clinical characteristics of community-acquired, methicillin-resistant versus methicillin-susceptible Staphylococcus aureus infection in children. Pediatr Infect Dis J. 2002; 21(10):910-7. DOI: 10.1097/00006454-200210000-00005. View

. Outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections--Los Angeles County, California, 2002-2003. MMWR Morb Mortal Wkly Rep. 2003; 52(5):88. View

Baggett H, Hennessy T, Leman R, Hamlin C, Bruden D, Reasonover A . An outbreak of community-onset methicillin-resistant Staphylococcus aureus skin infections in southwestern Alaska. Infect Control Hosp Epidemiol. 2003; 24(6):397-402. DOI: 10.1086/502221. View

. Methicillin-resistant staphylococcus aureus infections among competitive sports participants--Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000-2003. MMWR Morb Mortal Wkly Rep. 2003; 52(33):793-5. View

10.

Vandenesch F, Naimi T, Enright M, Lina G, Nimmo G, Heffernan H . Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis. 2003; 9(8):978-84. PMC: 3020611. DOI: 10.3201/eid0908.030089. View

11.

Siberry G, Tekle T, Carroll K, Dick J . Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro. Clin Infect Dis. 2003; 37(9):1257-60. DOI: 10.1086/377501. View

12.

McDougal L, Steward C, Killgore G, Chaitram J, McAllister S, Tenover F . Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J Clin Microbiol. 2003; 41(11):5113-20. PMC: 262524. DOI: 10.1128/JCM.41.11.5113-5120.2003. View

13.

Naimi T, LeDell K, Como-Sabetti K, Borchardt S, Boxrud D, Etienne J . Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA. 2003; 290(22):2976-84. DOI: 10.1001/jama.290.22.2976. View

14.

Schreckenberger P, Ilendo E, Ristow K . Incidence of constitutive and inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci in a community and a tertiary care hospital. J Clin Microbiol. 2004; 42(6):2777-9. PMC: 427875. DOI: 10.1128/JCM.42.6.2777-2779.2004. View

15.

Buckingham S, McDougal L, Cathey L, Comeaux K, Craig A, Fridkin S . Emergence of community-associated methicillin-resistant Staphylococcus aureus at a Memphis, Tennessee Children's Hospital. Pediatr Infect Dis J. 2004; 23(7):619-24. DOI: 10.1097/01.inf.0000131981.67342.c4. View

16.

Campbell K, Vaughn A, Russell K, Smith B, Jimenez D, Barrozo C . Risk factors for community-associated methicillin-resistant Staphylococcus aureus infections in an outbreak of disease among military trainees in San Diego, California, in 2002. J Clin Microbiol. 2004; 42(9):4050-3. PMC: 516279. DOI: 10.1128/JCM.42.9.4050-4053.2004. View

17.

McGehee RF R, Barre F, FINLAND M . Resistance of Staphylococcus aureus to lincomycin, clinimycin, and erythromycin. Antimicrob Agents Chemother (Bethesda). 1968; 8:392-7. View

18.

Halperin M, Blackwelder W, Verter J . Estimation of the multivariate logistic risk function: a comparison of the discriminant function and maximum likelihood approaches. J Chronic Dis. 1971; 24(2):125-58. DOI: 10.1016/0021-9681(71)90106-8. View

19.

Sanchez M, Flint K, Jones R . Occurrence of macrolide-lincosamide-streptogramin resistances among staphylococcal clinical isolates at a university medical center. Is false susceptibility to new macrolides and clindamycin a contemporary clinical and in vitro testing problem?. Diagn Microbiol Infect Dis. 1993; 16(3):205-13. DOI: 10.1016/0732-8893(93)90111-j. View

20.

. From the Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus--Minnesota and North Dakota, 1997-1999. JAMA. 1999; 282(12):1123-5. View