Coexistence of Mcr-1 and BlaNDM-1 in Escherichia Coli from Venezuela

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2016 Jul 20

PMID 27431212

Citations 54

Authors

Jose F Delgado-Blas

Cristina M Ovejero

Lorena Abadia-Patino

Bruno Gonzalez-Zorn

Affiliations

Soon will be listed here.

Abstract

We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.

Citing Articles

Detecting Class 1 Integrons and Their Variable Regions in Whole-Genome Sequences Reported from Andean Community Countries.

Solis M, Loaiza K, Torres-Elizalde L, Mina I, Sefcova M, Larrea-Alvarez M Antibiotics (Basel). 2024; 13(5).

PMID: 38786123 PMC: 11117327. DOI: 10.3390/antibiotics13050394.

Situation Report on mcr-Carrying Colistin-Resistant Clones of Enterobacterales: A Global Update Through Human-Animal-Environment Interfaces.

Biswas U, Das S, Barik M, Mallick A Curr Microbiol. 2023; 81(1):12.

PMID: 37989899 DOI: 10.1007/s00284-023-03521-8.

Isolation and Characterization of Carbapenem-Resistant Carrying and from Recurrent Urinary Tract Infection Patient.

Chen L, Jian J, Xie Z, Zhao P, Zhang M Can J Infect Dis Med Microbiol. 2023; 2023:6640009.

PMID: 37680456 PMC: 10482531. DOI: 10.1155/2023/6640009.

Antimicrobial resistance and One Health.

Serna C, Gonzalez-Zorn B Rev Esp Quimioter. 2022; 35 Suppl 3:37-40.

PMID: 36285856 PMC: 9717456. DOI: 10.37201/req/s03.09.2022.

An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli.

Khuntayaporn P, Thirapanmethee K, Chomnawang M Front Cell Infect Microbiol. 2022; 12:882236.

PMID: 35782127 PMC: 9248837. DOI: 10.3389/fcimb.2022.882236.

References

Kazmierczak K, Rabine S, Hackel M, McLaughlin R, Biedenbach D, Bouchillon S . Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2015; 60(2):1067-78. PMC: 4750703. DOI: 10.1128/AAC.02379-15. View

Kearse M, Moir R, Wilson A, Stones-Havas S, Cheung M, Sturrock S . Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics. 2012; 28(12):1647-9. PMC: 3371832. DOI: 10.1093/bioinformatics/bts199. View

Fernandes M, Moura Q, Sartori L, Silva K, Cunha M, Esposito F . Silent dissemination of colistin-resistant Escherichia coli in South America could contribute to the global spread of the mcr-1 gene. Euro Surveill. 2016; 21(17). DOI: 10.2807/1560-7917.ES.2016.21.17.30214. View

Skov R, Monnet D . Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill. 2016; 21(9):30155. DOI: 10.2807/1560-7917.ES.2016.21.9.30155. View

Wei W, Yang H, Ye Y, Li J . New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis, Treatment and Public Health Concern. Chin Med J (Engl). 2015; 128(14):1969-76. PMC: 4717920. DOI: 10.4103/0366-6999.160566. View

Yu H, Qu F, Shan B, Huang B, Jia W, Chen C . Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China. Antimicrob Agents Chemother. 2016; 60(8):5033-5. PMC: 4958199. DOI: 10.1128/AAC.00440-16. View

Rossolini G . Extensively drug-resistant carbapenemase-producing Enterobacteriaceae: an emerging challenge for clinicians and healthcare systems. J Intern Med. 2015; 277(5):528-31. DOI: 10.1111/joim.12350. View

Rapoport M, Faccone D, Pasteran F, Ceriana P, Albornoz E, Petroni A . First Description of mcr-1-Mediated Colistin Resistance in Human Infections Caused by Escherichia coli in Latin America. Antimicrob Agents Chemother. 2016; 60(7):4412-3. PMC: 4914662. DOI: 10.1128/AAC.00573-16. View

Liu Y, Wang Y, Walsh T, Yi L, Zhang R, Spencer J . Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2015; 16(2):161-8. DOI: 10.1016/S1473-3099(15)00424-7. View

10.

Delannoy S, Beutin L, Fach P . Towards a molecular definition of enterohemorrhagic Escherichia coli (EHEC): detection of genes located on O island 57 as markers to distinguish EHEC from closely related enteropathogenic E. coli strains. J Clin Microbiol. 2013; 51(4):1083-8. PMC: 3666763. DOI: 10.1128/JCM.02864-12. View

11.

Catry B, Cavaleri M, Baptiste K, Grave K, Grein K, Holm A . Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health. Int J Antimicrob Agents. 2015; 46(3):297-306. DOI: 10.1016/j.ijantimicag.2015.06.005. View

12.

Seija V, Medina Presentado J, Bado I, Papa Ezdra R, Batista N, Gutierrez C . Sepsis caused by New Delhi metallo-β-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review. Int J Infect Dis. 2014; 30:20-6. DOI: 10.1016/j.ijid.2014.09.010. View