New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2016 Jul 19

PMID 27429711

Citations 28

Authors

Jose Pedraza-Chaverri

Laura G Sanchez-Lozada

Horacio Osorio-Alonso

Edilia Tapia

Alexandra Scholze

Affiliations

Soon will be listed here.

Abstract

In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress. This review focuses on current pathogenic concepts of oxidative stress for the decline of kidney function and development of cardiovascular complications. We discuss the impact of mitochondrial alterations and dysfunction, a pathogenic role for hyperuricemia, and disturbances of vitamin D metabolism and signal transduction. Recent antioxidant therapy options including the use of vitamin D and pharmacologic therapies for hyperuricemia are discussed. Finally, we review some new therapy options in diabetic nephropathy including antidiabetic agents (noninsulin dependent), plant antioxidants, and food components as alternative antioxidant therapies.

Citing Articles

Sodium-Glucose Cotransporter Inhibitors: Cellular Mechanisms Involved in the Lipid Metabolism and the Treatment of Chronic Kidney Disease Associated with Metabolic Syndrome.

Cortes-Camacho F, Zambrano-Vasquez O, Arechaga-Ocampo E, Castaneda-Sanchez J, Gonzaga-Sanchez J, Sanchez-Gloria J Antioxidants (Basel). 2024; 13(7).

PMID: 39061837 PMC: 11274291. DOI: 10.3390/antiox13070768.

Pathophysiological concepts and screening of cardiovascular disease in dialysis patients.

Echefu G, Stowe I, Burka S, Basu-Ray I, Kumbala D Front Nephrol. 2023; 3:1198560.

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The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease.

Stojanovic D, Stojanovic M, Milenkovic J, Velickov A, Ignjatovic A, Milojkovic M Cells. 2023; 12(12).

PMID: 37371077 PMC: 10297141. DOI: 10.3390/cells12121607.

Nrf2 Protein Serum Concentration in Human CKD Shows a Biphasic Behavior.

Rasmussen M, Hansen K, Scholze A Antioxidants (Basel). 2023; 12(4).

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Arabic gum ameliorates systemic modulation in Alloxan monohydrate-induced diabetic rats.

Ibrahim R, Abdelhafez H, El-Shamy S, Eid F, Mashaal A Sci Rep. 2023; 13(1):5005.

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