Pregnancy in Sickle Cell Disease Is a Very High-Risk Situation: An Observational Study

Overview

Journal Obstet Gynecol Int

Publisher Wiley

Specialty Gynecology & Obstetrics

Date 2016 Jul 13

PMID 27403164

Citations 21

Authors

Narcisse Elenga

Aurelie Adeline

John Balcaen

Tania Vaz

Melanie Calvez

Anne Terraz

Laetitia Accrombessi

Gabriel Carles

Affiliations

Soon will be listed here.

Abstract

Sickle cell disease is a serious genetic disorder affecting 1/235 births in French Guiana. This study aimed to describe the follow-up of pregnancies among sickle cell disease patients in Cayenne Hospital, in order to highlight the most reported complications. 62 records of pregnancies were analyzed among 44 females with sickle cell disease, between 2007 and 2013. Our results were compared to those of studies conducted in Brazil and Guadeloupe. There were 61 monofetal pregnancies and 2 twin pregnancies, 27 pregnancies among women with SS phenotype, 30 SC pregnancies, and five S-beta pregnancies. The study showed that the follow-up of patients was variable, but no maternal death was found. We also noted that the main maternofetal complications of pregnancies were anemia (36.5%), infection (31.7%), vasoocclusive crisis (20.6%), preeclampsia (17.5%), premature birth (11.1%), intrauterine growth retardation (15.9%), abnormal fetal heart rate (14.3%), and intrauterine fetal death (4.8%). Pregnancies were more at risk among women with SS phenotype. Pregnancy in sickle cell disease patients requires a supported multidisciplinary team including the primary care physician, the obstetrician, and the Integrated Center for Sickle Cell Disease.

Citing Articles

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Adverse pregnancy, fetal and neonatal outcomes in women with sickle cell disease in a Middle Eastern country.

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