Sickle Cell Disease and Pregnancy

Overview

Journal Mediterr J Hematol Infect Dis

Specialty Infectious Diseases

Date 2019 Jul 17

PMID 31308916

Citations 31

Authors

Dipty Jain

Prachi Atmapoojya

Roshan Colah

Pooja Lodha

Affiliations

Soon will be listed here.

Abstract

Sickle cell disease (SCD) is the most common inherited hemoglobinopathy and is associated with increased risk of complications and early mortality. Nowadays, with improved health care facilities, antibiotic prophylaxis, vaccination, and availability of drugs like hydroxyurea, the life expectancy of SCD patients has improved. More women are reaching reproductive age group and are expressing their desire to reproduce. Though SCD adversely affects pregnancy, leading to increased incidence of maternal and perinatal complications like pre-eclampsia, preterm labor, IUGR, abortions etc., adequate care throughout pregnancy ensures a better outcome. Also, recent advancements in the fields of prenatal diagnosis and preimplantation genetic diagnosis, help couples suffering from SCD to have a healthy baby. This paper focuses on the effects of SCD on pregnancy outcomes and effective management of complications during pregnancy, also comparing maternal and perinatal outcomes in studies conducted in different countries. The second part of the paper summarizes pregnancy management in SCD for better maternal and fetal outcomes.

Citing Articles

Histomorphology of placentae of women with sickle cell disease during pregnancy - A case control study.

Mumuni M, Adutwum-Ofosu K, Arko-Boham B, Hottor B, Koney N, Adu-Bonsaffoh K PLoS One. 2025; 20(2):e0319011.

PMID: 39992941 PMC: 11849815. DOI: 10.1371/journal.pone.0319011.

Prophylactic vs therapeutic blood transfusions impact on pregnant sickle cell patients.

Imran I, Nazir I, Rfaai R, Khalil K Pak J Med Sci. 2025; 41(1):44-48.

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Rare association of posterior reversible encephalopathy syndrome (PRES) with hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome - A case report and review of the literature.

Zdraljevic M, Pejovic A, Jocic-Pivac B, Budimkic M, Jovanovic D, Mijajlovic M Heliyon. 2025; 10(24):e40915.

PMID: 39802606 PMC: 11724767. DOI: 10.1016/j.heliyon.2024.e40915.

Pregnancy Outcomes Among Women With Sickle Cell Disease in Bahrain: A Case-Control Study.

Marhoon B, Marzooq A, Alasfoor H, Albalooshi S Cureus. 2024; 16(7):e64995.

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Racial/ethnic differences in pre-pregnancy conditions and adverse maternal outcomes in the nuMoM2b cohort: A population-based cohort study.

Meredith M, Steimle L, Stanhope K, Platner M, Boulet S PLoS One. 2024; 19(8):e0306206.

PMID: 39133734 PMC: 11318875. DOI: 10.1371/journal.pone.0306206.

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