» Articles » PMID: 27398264

The Effects of Dietary Omega-3s on Muscle Composition and Quality in Older Adults

Overview
Journal Curr Nutr Rep
Date 2016 Jul 12
PMID 27398264
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

This review will focus on findings from the few studies performed to date in humans to examine changes in muscle protein turnover, lean or muscle mass and physical function following fish oil-derived omega-3 fatty acid treatment. Although considerable gaps in our current knowledge exist, hypertrophic responses (e.g., improvements in the rate of muscle protein synthesis and mTOR signaling during increased amino acid availability and an increase in muscle volume) have been reported in older adults following prolonged (8 to 24 weeks) of omega-3 fatty acid supplementation. There is also accumulating evidence that increased omega-3 fatty acid levels in red blood cells are positively related to strength and measures of physical function. As a result, increased omega-3 fatty acid consumption may prove to be a promising low-cost dietary approach to attenuate or prevent aging associated declines in muscle mass and function.

Citing Articles

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.

Nilsson M, Mikhail A, Lan L, Di Carlo A, Hamilton B, Barnard K Nutrients. 2020; 12(8).

PMID: 32785021 PMC: 7468764. DOI: 10.3390/nu12082391.


Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia.

Damanti S, Azzolino D, Roncaglione C, Arosio B, Rossi P, Cesari M Nutrients. 2019; 11(9).

PMID: 31443594 PMC: 6770476. DOI: 10.3390/nu11091991.


The Role of Inflammation in Age-Related Sarcopenia.

Dalle S, Rossmeislova L, Koppo K Front Physiol. 2018; 8:1045.

PMID: 29311975 PMC: 5733049. DOI: 10.3389/fphys.2017.01045.


Does nutrition play a role in the prevention and management of sarcopenia?.

Robinson S, Reginster J, Rizzoli R, Shaw S, Kanis J, Bautmans I Clin Nutr. 2017; 37(4):1121-1132.

PMID: 28927897 PMC: 5796643. DOI: 10.1016/j.clnu.2017.08.016.

References
1.
Gingras A, White P, Chouinard P, Julien P, Davis T, Dombrowski L . Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity. J Physiol. 2006; 579(Pt 1):269-84. PMC: 2075371. DOI: 10.1113/jphysiol.2006.121079. View

2.
Robinson S, Jameson K, Batelaan S, Martin H, Syddall H, Dennison E . Diet and its relationship with grip strength in community-dwelling older men and women: the Hertfordshire cohort study. J Am Geriatr Soc. 2007; 56(1):84-90. PMC: 2493054. DOI: 10.1111/j.1532-5415.2007.01478.x. View

3.
Goodpaster B, Park S, Harris T, Kritchevsky S, Nevitt M, Schwartz A . The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006; 61(10):1059-64. DOI: 10.1093/gerona/61.10.1059. View

4.
Beck S, Smith K, Tisdale M . Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover. Cancer Res. 1991; 51(22):6089-93. View

5.
Papanikolaou Y, Brooks J, Reider C, Fulgoni 3rd V . U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. Nutr J. 2014; 13:31. PMC: 3992162. DOI: 10.1186/1475-2891-13-31. View