O-demethylation and N4-acetylation of Sulfadimethoxine by the Snail Cepaea Hortensis

Overview

Journal Nihon Juigaku Zasshi

Specialty Veterinary Medicine

Date 1989 Apr 1

PMID 2739212

Citations 3

Authors

T B Vree

M L Vree

E W Beneken Kolmer

Y A Hekster

M Shimoda

J F Nouws

T Yoshioka

K HOJI

Affiliations

Soon will be listed here.

Abstract

The snail Cepaea hortensis O-dealkylates sulfadimethoxine at the 2- and 6-position, the 2-position being favoured. Sulfadimethoxine is also acetylated, while no measurable acetylation of the hydroxy (= demethyl) metabolites took place.

Citing Articles

Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.

Vree T, Beneken Kolmer E, Martea M, Bosch R, Hekster Y, Shimoda M Pharm Weekbl Sci. 1990; 12(2):51-9.

PMID: 2336339 DOI: 10.1007/BF01970146.

High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.

Vree T, Beneken Kolmer E, Hekster Y Pharm Weekbl Sci. 1990; 12(6):243-6.

PMID: 2091020 DOI: 10.1007/BF01967825.

Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfamethomidine in humans.

Vree T, Beneken Kolmer E, Hekster Y Pharm Weekbl Sci. 1991; 13(5):198-206.

PMID: 1749708 DOI: 10.1007/BF01988875.