High Pressure Liquid Chromatographic Analysis and Preliminary Pharmacokinetics of Sulfaphenazole and Its N2-glucuronide and N4-acetyl Metabolites in Plasma and Urine of Man

Overview

Journal Pharm Weekbl Sci

Specialty Pharmacy

Date 1990 Dec 14

PMID 2091020

Citations 5

Authors

T B Vree

E W Beneken Kolmer

Y A Hekster

Affiliations

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Abstract

A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, less than 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.

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