Genes Regulated by Potassium Channel Tetramerization Domain Containing 15 (Kctd15) in the Developing Neural Crest

Overview

Journal Int J Dev Biol

Specialties Biology
Reproductive Medicine

Date 2016 Jul 9

PMID 27389986

Citations 13

Authors

Thomas C B Wong

Martha Rebbert

Chengdong Wang

Xiongfong Chen

Alison Heffer

Valeria E Zarelli

Igor B Dawid

Hui Zhao

Affiliations

Soon will be listed here.

Abstract

Neural crest (NC) development is controlled precisely by a regulatory network with multiple signaling pathways and the involvement of many genes. The integration and coordination of these factors are still incompletely understood. Overexpression of Wnt3a and the BMP antagonist Chordin in animal cap cells from Xenopus blastulae induces a large number of NC specific genes. We previously suggested that Potassium Channel Tetramerization Domain containing 15 (Kctd15) regulates NC formation by affecting Wnt signaling and the activity of transcription factor AP-2. In order to advance understanding of the function of Kctd15 during NC development, we performed DNA microarray assays in explants injected with Wnt3a and Chordin, and identified genes that are affected by Kctd15 overexpression. Among the many genes identified, we chose Duf domain containing protein 1 (ddcp1), Platelet-Derived Growth Factor Receptor a (pdgfra), Complement factor properdin (cfp), Zinc Finger SWIM-Type Containing 5 (zswim5), and complement component 3 (C3) to examine their expression by whole mount in situ hybridization. Our work points to a possible role for Kctd15 in the regulation of NC formation and other steps in embryonic development.

Citing Articles

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Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation.

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A Comprehensive Analysis of the Structural Recognition between KCTD Proteins and Cullin 3.

Balasco N, Esposito L, Smaldone G, Salvatore M, Vitagliano L Int J Mol Sci. 2024; 25(3).

PMID: 38339159 PMC: 10856315. DOI: 10.3390/ijms25031881.

ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation.

Wang C, Liu Z, Zeng Y, Zhou L, Long Q, Ul Hassan I EMBO Rep. 2024; 25(2):646-671.

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