The Role of MicroRNAs in Respiratory Viral Infection: Friend or Foe?

Overview

Journal Rev Med Virol

Publisher Wiley

Specialty Microbiology

Date 2016 Jul 5

PMID 27373545

Citations 32

Authors

Alireza Tahamtan

Christopher S Inchley

Mona Marzban

Masoumeh Tavakoli-Yaraki

Majid Teymoori-Rad

Britt Nakstad

Vahid Salimi

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) have emerged as a class of regulatory RNAs in host-pathogen interactions. Aberrant miRNA expression seems to play a central role in the pathology of several respiratory viruses, promoting development and progression of infection. miRNAs may thus serve as therapeutic and prognostic factors for respiratory viral infectious disease caused by a variety of agents. We present a comprehensive review of recent findings related to the role of miRNAs in different respiratory viral infections and discuss possible therapeutic opportunities aiming to attenuate the burden of viral infections. Our review supports the emerging concept that cellular and viral-encoded miRNAs might be broadly implicated in human respiratory viral infections, with either positive or negative effects on virus life cycle. Copyright © 2016 John Wiley & Sons, Ltd.

Citing Articles

miR-27a-5p, miR-21-5p, miR-1246 and miR-4508: a candidate microRNA signature in the protection and regulation of viral infection in mild COVID-19.

Gajate-Arenas M, Sirvent-Blanco C, Garcia-Perez O, Dominguez-de-Barros A, Pinero J, Lorenzo-Morales J Mol Med. 2025; 31(1):102.

PMID: 40089674 DOI: 10.1186/s10020-025-01154-0.

Primer exchange reaction assisted CRISPR/Cas9 cleavage for detection of dual microRNAs with electrochemistry method.

Zhou Y, Che S, Wang Z, Zhang X, Yuan X Mikrochim Acta. 2024; 191(8):502.

PMID: 39093358 DOI: 10.1007/s00604-024-06548-1.

Distinct Effects of Respiratory Viral Infection Models on miR-149-5p, IL-6 and p63 Expression in BEAS-2B and A549 Epithelial Cells.

Shahdab N, Ward C, Hansbro P, Cummings S, Young J, Moheimani F Cells. 2024; 13(11.

PMID: 38891051 PMC: 11172188. DOI: 10.3390/cells13110919.

Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis.

Zhang C, Zhang Y, Zhuang R, Yang K, Chen L, Jin B Int J Mol Sci. 2024; 25(8).

PMID: 38674036 PMC: 11050295. DOI: 10.3390/ijms25084451.

Viral MicroRNAs in Herpes Simplex Virus 1 Pathobiology.

Naqvi R, Valverde A, Yadavalli T, Bobat F, Capistrano K, Shukla D Curr Pharm Des. 2024; 30(9):649-665.

PMID: 38347772 DOI: 10.2174/0113816128286469240129100313.

References

Trgovcich J, Cebulla C, Zimmerman P, Sedmak D . Human cytomegalovirus protein pp71 disrupts major histocompatibility complex class I cell surface expression. J Virol. 2005; 80(2):951-63. PMC: 1346885. DOI: 10.1128/JVI.80.2.951-963.2006. View

Landais I, Pelton C, Streblow D, DeFilippis V, McWeeney S, Nelson J . Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway. PLoS Pathog. 2015; 11(5):e1004881. PMC: 4425655. DOI: 10.1371/journal.ppat.1004881. View

Salimi V, Tavakoli-Yaraki M, Yavarian J, Bont L, Mokhtari-Azad T . Prevalence of human respiratory syncytial virus circulating in Iran. J Infect Public Health. 2015; 9(2):125-35. DOI: 10.1016/j.jiph.2015.05.005. View

Buggele W, Johnson K, Horvath C . Influenza A virus infection of human respiratory cells induces primary microRNA expression. J Biol Chem. 2012; 287(37):31027-40. PMC: 3438935. DOI: 10.1074/jbc.M112.387670. View

Muller S, Imler J . Dicing with viruses: microRNAs as antiviral factors. Immunity. 2007; 27(1):1-3. DOI: 10.1016/j.immuni.2007.07.003. View

Li Y, Li J, Belisle S, Baskin C, Tumpey T, Katze M . Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses. Virology. 2011; 421(2):105-13. PMC: 3210927. DOI: 10.1016/j.virol.2011.09.011. View

Lynch 3rd J, Fishbein M, Echavarria M . Adenovirus. Semin Respir Crit Care Med. 2011; 32(4):494-511. DOI: 10.1055/s-0031-1283287. View

Yanagawa-Matsuda A, Kitamura T, Higashino F, Yamano S, Totsuka Y, Shindoh M . E1A expression might be controlled by miR-214 in cells with low adenovirus productivity. Virus Res. 2012; 170(1-2):85-90. DOI: 10.1016/j.virusres.2012.09.001. View

Ksiazek T, Erdman D, Goldsmith C, Zaki S, Peret T, Emery S . A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1953-66. DOI: 10.1056/NEJMoa030781. View

10.

Gomez-Diaz E, Jorda M, Peinado M, Rivero A . Epigenetics of host-pathogen interactions: the road ahead and the road behind. PLoS Pathog. 2012; 8(11):e1003007. PMC: 3510240. DOI: 10.1371/journal.ppat.1003007. View

11.

Lee S, Kalejta R, Kerry J, Semmes O, OConnor C, Khan Z . BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2012; 109(24):9575-80. PMC: 3386064. DOI: 10.1073/pnas.1207496109. View

12.

Guo Y, Steitz J . Virus meets host microRNA: the destroyer, the booster, the hijacker. Mol Cell Biol. 2014; 34(20):3780-7. PMC: 4187717. DOI: 10.1128/MCB.00871-14. View

13.

Zhong Z, Dong Z, Yang L, Gong Z . miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer. J Cancer Res Clin Oncol. 2012; 138(10):1781-8. DOI: 10.1007/s00432-012-1287-y. View

14.

Inchley C, Sonerud T, Fjaerli H, Nakstad B . Reduced Dicer expression in the cord blood of infants admitted with severe respiratory syncytial virus disease. BMC Infect Dis. 2011; 11:59. PMC: 3061906. DOI: 10.1186/1471-2334-11-59. View

15.

Stark T, Arnold J, Spector D, Yeo G . High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection. J Virol. 2011; 86(1):226-35. PMC: 3255895. DOI: 10.1128/JVI.05903-11. View

16.

Graff J, Dickson A, Clay G, McCaffrey A, Wilson M . Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem. 2012; 287(26):21816-25. PMC: 3381144. DOI: 10.1074/jbc.M111.327031. View

17.

Stewart C, Marsh G, Jenkins K, Gantier M, Tizard M, Middleton D . Promotion of Hendra virus replication by microRNA 146a. J Virol. 2013; 87(7):3782-91. PMC: 3624204. DOI: 10.1128/JVI.01342-12. View

18.

Cullen B . Viruses and microRNAs: RISCy interactions with serious consequences. Genes Dev. 2011; 25(18):1881-94. PMC: 3185961. DOI: 10.1101/gad.17352611. View

19.

Babu S, Pandeya A, Verma N, Shukla N, Kumar R, Saxena S . Role of HCMV miR-UL70-3p and miR-UL148D in overcoming the cellular apoptosis. Mol Cell Biochem. 2014; 393(1-2):89-98. DOI: 10.1007/s11010-014-2049-8. View

20.

Aparicio O, Razquin N, Zaratiegui M, Narvaiza I, Fortes P . Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production. J Virol. 2006; 80(3):1376-84. PMC: 1346933. DOI: 10.1128/JVI.80.3.1376-1384.2006. View