Successful Implementation of Lynch Syndrome Screening in a Safety Net Institution

Overview

Journal J Community Genet

Publisher Springer

Specialty Health Services

Date 2016 Jul 4

PMID 27372833

Citations 4

Authors

Trilokesh D Kidambi

Robin Lee

Jonathan P Terdiman

Lukejohn Day

Affiliations

Soon will be listed here.

Abstract

Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer (CRC), and national guidelines recommend screening patients with CRC for LS. However, there is a paucity of data related to Lynch syndrome in the underserved population, in which unique issues of access, cultural beliefs regarding cancer, language barriers, immigration status, and financial restraints exist. We performed a descriptive, retrospective review of a selective LS screening protocol at an urban safety net hospital between 2009 and 2014 with the aim of describing the detected prevalence of LS as well as reporting the high quality and suboptimal screening rates. A total of 154 cases of CRC were identified over the 5-year period, of which 57 met selective LS screening criteria. Eleven patients had a positive screen, and three patients were diagnosed with LS, leading to an overall detected LS prevalence of 1.9 %. The rate of high quality screen was greater than 90 %, consistent with prior studies. Thus, we show that screening for LS in a safety net hospital can be successful in achieving high quality screening and provide an example for other public hospitals considering implementation of hereditary cancer screening.

Citing Articles

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How Should We Test for Lynch Syndrome? A Review of Current Guidelines and Future Strategies.

Gallon R, Gawthorpe P, Phelps R, Hayes C, Borthwick G, Santibanez-Koref M Cancers (Basel). 2021; 13(3).

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Universal tumor screening for Lynch syndrome: perspectives of Canadian pathologists and genetic counselors.

Dicks E, Pullman D, Kao K, MacMillan A, Simmonds C, Etchegary H J Community Genet. 2018; 10(3):335-344.

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A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification.

Tognetto A, Michelazzo M, Calabro G, Unim B, DI Marco M, Ricciardi W Front Public Health. 2017; 5:243.

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