Pericardial Patch Venoplasty Heals Via Attraction of Venous Progenitor Cells

Overview

Journal Physiol Rep

Specialty Physiology

Date 2016 Jun 30

PMID 27354544

Citations 14

Authors

Hualong Bai

Mo Wang

Trenton R Foster

Haidi Hu

Hao He

Takuya Hashimoto

Jesse J Hanisch

Jeans M Santana

Ying Xing

Alan Dardik

Affiliations

Soon will be listed here.

Abstract

Pericardial patches are commonly used during cardiovascular surgery to close blood vessels. In arteries, patches accumulate arterial progenitor cells; we hypothesized that venous patches would accumulate venous progenitor cells, in the absence of arterial pressure. We developed a novel rat inferior vena cava (IVC) venotomy model and repaired it with a pericardial patch. Cells infiltrated the patch to form a thick neointima by day 7; some cells were CD34(+)/VEGFR2(+) and CD31(+)/Eph-B4(+) consistent with development of venous identity in the healing patch. Compared to arterial patches, the venous patches had increased neointimal thickness at day 7 without any pseudoaneurysms. Addition of an arteriovenous fistula (AVF) to increase blood flow on the patch resulted in reduced patch neointimal thickness and proliferation, but neointimal thickness was not reversible with AVF ligation. These results show that rat patch venoplasty is a novel model of aggressive venous neointimal hyperplasia.

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References

Dardik A, Perler B, Roseborough G, Williams G . Aneurysmal expansion of the visceral patch after thoracoabdominal aortic replacement: an argument for limiting patch size?. J Vasc Surg. 2001; 34(3):405-9; discussion 410. DOI: 10.1067/mva.2001.117149. View

Biasi G, Sternjakob S, Mingazzini P, Ferrari S . Nine-year experience of bovine pericardium patch angioplasty during carotid endarterectomy. J Vasc Surg. 2002; 36(2):271-7. DOI: 10.1067/mva.2002.123685. View

Wheeler J, Wright I, Pugh N, Lane I . Is there carotid artery aneurysm formation following saphenous vein patch endarterectomy?. Cardiovasc Surg. 2000; 8(1):47-50. DOI: 10.1016/s0967-2109(99)00085-x. View

Bai H, Wang M, Foster T, Hu H, He H, Hashimoto T . Pericardial patch venoplasty heals via attraction of venous progenitor cells. Physiol Rep. 2016; 4(12). PMC: 4923240. DOI: 10.14814/phy2.12841. View

Bai H, Kuwahara G, Wang M, Brownson K, Foster T, Yamamoto K . Pretreatment of pericardial patches with antibiotics does not alter patch healing in vivo. J Vasc Surg. 2014; 63(4):1063-73. PMC: 4422782. DOI: 10.1016/j.jvs.2014.09.067. View

Shi Q, Wu M, Onuki Y, Kouchi Y, Ghali R, Wechezak A . The effect of flow shear stress on endothelialization of impervious Dacron grafts from circulating cells in the arterial and venous systems of the same dog. Ann Vasc Surg. 1998; 12(4):341-8. DOI: 10.1007/s100169900165. View

Mori A, Kaido T, Ogura Y, Ogawa K, Hata K, Yagi S . Standard hepatic vein reconstruction with patch plasty using the native portal vein in adult living donor liver transplantation. Liver Transpl. 2012; 18(5):602-7. DOI: 10.1002/lt.23387. View

Wang H, Chen Z, Anderson D . Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998; 93(5):741-53. DOI: 10.1016/s0092-8674(00)81436-1. View

Chang Y, Liang H, Wei H, Chu C, Sung H . Tissue regeneration patterns in acellular bovine pericardia implanted in a canine model as a vascular patch. J Biomed Mater Res A. 2004; 69(2):323-33. DOI: 10.1002/jbm.a.30003. View

10.

Kohler T, Kirkman T, Kraiss L, Zierler B, Clowes A . Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts. Circ Res. 1991; 69(6):1557-65. DOI: 10.1161/01.res.69.6.1557. View

11.

McMillan W, Leville C, Hile C . Bovine pericardial patch repair in infected fields. J Vasc Surg. 2012; 55(6):1712-5. DOI: 10.1016/j.jvs.2011.11.139. View

12.

Fann J, Sokoloff M, Sarris G, Yun K, KOSEK J, Miller D . The reversibility of canine vein-graft arterialization. Circulation. 1990; 82(5 Suppl):IV9-18. View

13.

Ellenby M, Ernst C, Carretero O, Scicli A . Role of nitric oxide in the effect of blood flow on neointima formation. J Vasc Surg. 1996; 23(2):314-22. DOI: 10.1016/s0741-5214(96)70276-8. View

14.

Richter G, Palmaz J, Noeldge G, Tio F . Relationship between blood flow, thrombus, and neointima in stents. J Vasc Interv Radiol. 1999; 10(5):598-604. DOI: 10.1016/s1051-0443(99)70090-4. View

15.

Papakostas J, Avgos S, Arnaoutoglou E, Nassis C, Peroulis M, Bali C . Use of the vascu-guard bovine pericardium patch for arteriotomy closure in carotid endarterectomy. Early and long-term results. Ann Vasc Surg. 2013; 28(5):1213-8. DOI: 10.1016/j.avsg.2013.10.021. View

16.

Del Campo C, Konok G . Use of a pericardial xenograft patch in repair of resected retrohepatic vena cava. Can J Surg. 1994; 37(1):59-61. View

17.

Chang Y, Tsai C, Liang H, Sung H . In vivo evaluation of cellular and acellular bovine pericardia fixed with a naturally occurring crosslinking agent (genipin). Biomaterials. 2002; 23(12):2447-57. DOI: 10.1016/s0142-9612(01)00379-9. View

18.

Liang A, Wang Y, Han G, Truong L, Cheng J . Chronic kidney disease accelerates endothelial barrier dysfunction in a mouse model of an arteriovenous fistula. Am J Physiol Renal Physiol. 2013; 304(12):F1413-20. PMC: 3680675. DOI: 10.1152/ajprenal.00585.2012. View

19.

Yamamoto K, Protack C, Tsuneki M, Hall M, Wong D, Lu D . The mouse aortocaval fistula recapitulates human arteriovenous fistula maturation. Am J Physiol Heart Circ Physiol. 2013; 305(12):H1718-25. PMC: 3882542. DOI: 10.1152/ajpheart.00590.2013. View

20.

Li X, Guo Y, Ziegler K, Model L, Eghbalieh S, Brenes R . Current usage and future directions for the bovine pericardial patch. Ann Vasc Surg. 2011; 25(4):561-8. PMC: 3085588. DOI: 10.1016/j.avsg.2010.11.007. View