1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2016 Jun 29

PMID 27351430

Citations 31

Authors

Yun Li

Yanni Lai

Yao Wang

Ni Liu

Fengxue Zhang

Peiping Xu

Affiliations

Soon will be listed here.

Abstract

1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects against influenza viral infection in mice. Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1β, IL-6, TNF-α, and IFN-γ in lung tissues of mice infected with influenza virus. The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Thus, 1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.

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