The Fukuoka Kidney Disease Registry (FKR) Study: Design and Methods

Overview

Journal Clin Exp Nephrol

Publisher Springer

Specialty Nephrology

Date 2016 Jun 25

PMID 27339444

Citations 16

Authors

Shigeru Tanaka

Toshiharu Ninomiya

Kiichiro Fujisaki

Hisako Yoshida

Masaharu Nagata

Kosuke Masutani

Masanori Tokumoto

Koji Mitsuiki

Hideki Hirakata

Satoru Fujimi

Yutaka Kiyohara

Takanari Kitazono

Kazuhiko Tsuruya

Affiliations

Soon will be listed here.

Abstract

Background: Chronic kidney disease (CKD) is an established independent risk factor for progression to end-stage renal disease (ESRD) and incidence of cardiovascular disease (CVD). The onset and progression of CKD are associated with both genetic predisposition and various lifestyle-related factors, but little is known about the influence of genetic-environmental interactions on the incidence of ESRD or CVD in patients with CKD.

Methods: The Fukuoka Kidney disease Registry (FKR) Study is designed as one of the largest prospective, multicenter, observational cohort studies in non-dialysis dependent CKD patients. The FKR Study aims to enroll approximately 5000 individuals at multiple clinical centers and follow them for up to at least 5 years. At baseline, subjects enrolled in the FKR Study will fill out extensive lifestyle-related questionnaires. Further, their health status and treatments will be monitored annually through a research network of nephrology centers. Blood and urine samples, including DNA/RNA, will be collected at the time of enrolment and every 5-years follow-up.

Conclusions: The FKR Study will provide many insights into the onset and progression of CKD, which will suggest hypothesis-driven interventional clinical trials aimed at reducing the burden of CKD. The features of the FKR Study may also facilitate innovative research to identify and validate novel risk factors, including genetic susceptibility and biomarkers, using biomaterials by high-throughput omics technologies.

Citing Articles

Combined evaluation of glomerular phospholipase A2 receptor and immunoglobulin G subclass in membranous nephropathy.

Ueki K, Tsuchimoto A, Matsukuma Y, Ataka E, Okamoto H, Tanaka S Clin Kidney J. 2024; 17(6):sfae104.

PMID: 38854426 PMC: 11161704. DOI: 10.1093/ckj/sfae104.

Associations between the Serum Triglyceride Level and Kidney Outcome in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry Study.

Seki M, Nakano T, Tanaka S, Kitamura H, Hiyamuta H, Ninomiya T J Atheroscler Thromb. 2024; 31(11):1556-1570.

PMID: 38735756 PMC: 11537783. DOI: 10.5551/jat.64625.

Impact of Age on Prescribing Patterns of Cardiovascular Medications in Older Japanese Patients with Non-Dialysis-Dependent Chronic Kidney Disease: A Cross-Sectional Study.

Tanaka S, Kitamura H, Tsuruya K, Kitazono T, Nakano T J Atheroscler Thromb. 2024; 31(10):1427-1442.

PMID: 38631869 PMC: 11456346. DOI: 10.5551/jat.64798.

Relationships of Weight Change from 20 Years of Age with the Risks of All-Cause and Cardiovascular Mortality in Patients with Chronic Kidney Disease.

Okamura K, Tanaka S, Kitamura H, Hiyamuta H, Tsuruya K, Nakano T J Atheroscler Thromb. 2024; 31(7):1072-1086.

PMID: 38267049 PMC: 11224694. DOI: 10.5551/jat.64571.

Prevalence of hyponatremia and associated factors in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry (FKR) study.

Inoue M, Nakai K, Tanaka S, Mitsuiki K, Tokumoto M, Tsuruya K Clin Exp Nephrol. 2023; 27(12):1023-1031.

PMID: 37642786 DOI: 10.1007/s10157-023-02395-1.

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