Angiotensin II Receptor Blockers and Bone Fracture in Chronic Kidney Disease Patients: the Fukuoka Kidney Disease Registry Study

Overview

Journal Clin Exp Nephrol

Publisher Springer

Specialty Nephrology

Date 2023 Jul 27

PMID 37498346

Authors

Tomoya Shukuri

Kentaro Nakai

Shigeru Tanaka

Shunsuke Yamada

Masanori Tokumoto

Kazuhiko Tsuruya

Toshiaki Nakano

Takanari Kitazono

Affiliations

Soon will be listed here.

Abstract

Background: Angiotensin II receptor blockers (ARBs) reportedly reduce the risk of developing bone fractures; however, this association remains unclear among patients with chronic kidney disease (CKD).

Methods: This was a cross-sectional study of 3380 CKD patients enrolled in the Fukuoka Kidney disease Registry Study, a multicenter prospective observational cohort study of non-dialysis-dependent CKD patients. The patients were divided into two groups, those taking ARBs and those who were not. Logistic regression models were used to examine the association between ARBs and bone fracture.

Results: Approximately 67.0% of the participants were on ARBs, and 6.3% had a history of bone fracture. The history of bone fracture was significantly lower in patients with prescribed ARB and remained significant even after multivariable adjustment (odds ratio, 0.68; 95% confidence interval, 0.51-0.93). Other antihypertensive drugs, such as thiazide diuretics, which were reportedly helpful in preventing fractures, did not alter the bone fracture history and did not change among ARB users and non-users.

Conclusions: The present study showed that administering ARB was significantly associated with a lower frequency of bone fracture history.

Citing Articles

Real-world fracture risk, osteoporosis treatment status, and mortality of Japanese non-dialysis patients with chronic kidney disease stages G3-5.

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