Multiple Roles of CD90 in Cancer

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2016 Jun 25

PMID 27337957

Citations 58

Authors

Atul Kumar

Anshuman Bhanja

Jina Bhattacharyya

Bithiah Grace Jaganathan

Affiliations

Soon will be listed here.

Abstract

THY1 (CD90) is a 25-37-kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein. It is usually expressed on thymocytes, mesenchymal stem cells, hematopoietic stem cells, natural killer cells, neurons, endothelial cells, renal glomerular mesangial cells, follicular dendritic cells, fibroblasts, and myofibroblasts. It has been found to regulate cell adhesion, migration, apoptosis, axon growth, cell-cell and cell-matrix interactions, T-cell activation, and fibrosis. Several reports have shown that CD90 has an important role in cancer in regulating cancer cell proliferation, metastasis, and angiogenesis. There are also evidences that CD90 is an important prognostic marker in many cancers. Consequently, therapies that target CD90 have great promise in treating many cancers. However, several studies also indicate a contradictory role for CD90, where it acts as a tumor suppressor. In this review, we summarize the expression, function of CD90 in different cancers and its possible use as a biomarker or a therapeutic target in cancer. The challenges and future prospects for the use of CD90 for clinical applications are also discussed in this review.

Citing Articles

Significance of CD70, VEGF, and CD90 Immunohistochemical Expression in Colorectal Cancer.

Aboushousha T, Osama M, Mohamed M, Khaled Y, Elmeligy H, Ossama Y Asian Pac J Cancer Prev. 2024; 25(10):3691-3699.

PMID: 39471037 PMC: 11711364. DOI: 10.31557/APJCP.2024.25.10.3691.

Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis.

Qian H, Deng C, Chen S, Zhang X, He Y, Lan J Arthritis Res Ther. 2024; 26(1):103.

PMID: 38783357 PMC: 11112866. DOI: 10.1186/s13075-024-03343-4.

CD14+ Dendritic-Shaped Cells Functioning as Dendritic Cells in Rheumatoid Arthritis Synovial Tissues.

Kurose R, Satoh T, Kurose A, Ishibashi Y, Uzuki M, Wakai Y ACR Open Rheumatol. 2024; 6(7):412-420.

PMID: 38638058 PMC: 11246827. DOI: 10.1002/acr2.11670.

Identification of Hub Genes and Prediction of Targeted Drugs for Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis.

Cui T, Huang Z, Luo K, Nie J, Xv Y, Zeng Z Biochem Genet. 2024; 62(6):5157-5178.

PMID: 38334875 DOI: 10.1007/s10528-023-10650-z.

Flow cytometric characterization of cell surface markers to differentiate between fibroblasts and mesenchymal stem cells of different origin.

Sober S, Darmani H, Alhattab D, Awidi A Arch Med Sci. 2023; 19(5):1487-1496.

PMID: 37732070 PMC: 10507789. DOI: 10.5114/aoms/131088.

References

Fujita N, Kodama N, Kato Y, Lee S, Tsuruo T . Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases. Exp Cell Res. 1997; 232(2):400-6. DOI: 10.1006/excr.1997.3505. View

Seki T, Spurr N, Obata F, Goyert S, Goodfellow P, Silver J . The human Thy-1 gene: structure and chromosomal location. Proc Natl Acad Sci U S A. 1985; 82(19):6657-61. PMC: 391269. DOI: 10.1073/pnas.82.19.6657. View

Notta F, Doulatov S, Laurenti E, Poeppl A, Jurisica I, Dick J . Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science. 2011; 333(6039):218-21. DOI: 10.1126/science.1201219. View

Abeysinghe H, Cao Q, Xu J, Pollock S, Veyberman Y, Guckert N . THY1 expression is associated with tumor suppression of human ovarian cancer. Cancer Genet Cytogenet. 2003; 143(2):125-32. DOI: 10.1016/s0165-4608(02)00855-5. View

Abeysinghe H, Pollock S, Guckert N, Veyberman Y, Keng P, Halterman M . The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 2004; 149(1):1-10. DOI: 10.1016/S0165-4608(03)00234-6. View

Pascal L, Ai J, Vencio R, Vencio E, Zhou Y, Page L . Differential Inductive Signaling of CD90 Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells. Cancer Microenviron. 2011; 4(1):51-9. PMC: 3047627. DOI: 10.1007/s12307-010-0061-4. View

He J, Liu Y, Zhu T, Zhu J, DiMeco F, Vescovi A . CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays. Mol Cell Proteomics. 2011; 11(6):M111.010744. PMC: 3433900. DOI: 10.1074/mcp.M111.010744. View

Tang K, Dai Y, Tong M, Chan Y, Kwan P, Fu L . A CD90(+) tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer. Cancer Res. 2013; 73(7):2322-32. DOI: 10.1158/0008-5472.CAN-12-2991. View

Gunter K, Germain R, Kroczek R, Saito T, Yokoyama W, Chan C . Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. Nature. 1987; 326(6112):505-7. DOI: 10.1038/326505a0. View

10.

Ho D, Yang Z, Yi K, Lam C, Ng M, Yu W . Gene expression profiling of liver cancer stem cells by RNA-sequencing. PLoS One. 2012; 7(5):e37159. PMC: 3351419. DOI: 10.1371/journal.pone.0037159. View

11.

Mutirangura A, Tanunyutthawongese C, Pornthanakasem W, Kerekhanjanarong V, Sriuranpong V, Yenrudi S . Genomic alterations in nasopharyngeal carcinoma: loss of heterozygosity and Epstein-Barr virus infection. Br J Cancer. 1997; 76(6):770-6. PMC: 2228030. DOI: 10.1038/bjc.1997.460. View

12.

Zhao H, Peehl D . Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts. Prostate. 2009; 69(9):991-1000. PMC: 2736596. DOI: 10.1002/pros.20946. View

13.

Yamazaki H, Nishida H, Iwata S, Dang N, Morimoto C . CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells. Biochem Biophys Res Commun. 2009; 383(2):172-7. DOI: 10.1016/j.bbrc.2009.03.127. View

14.

Dreyer E, Leifer D, HENG J, McConnell J, Gorla M, Levin L . An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth. Proc Natl Acad Sci U S A. 1995; 92(24):11195-9. PMC: 40598. DOI: 10.1073/pnas.92.24.11195. View

15.

Ishizu A, Ishikura H, Nakamaru Y, Kikuchi K, Koike T, Yoshiki T . Interleukin-1alpha regulates Thy-1 expression on rat vascular endothelial cells. Microvasc Res. 1997; 53(1):73-8. DOI: 10.1006/mvre.1996.1986. View

16.

Pont S . Thy-1: a lymphoid cell subset marker capable of delivering an activation signal to mouse T lymphocytes. Biochimie. 1987; 69(4):315-20. DOI: 10.1016/0300-9084(87)90022-8. View

17.

Karagiannis G, Poutahidis T, Erdman S, Kirsch R, Riddell R, Diamandis E . Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res. 2012; 10(11):1403-18. PMC: 4399759. DOI: 10.1158/1541-7786.MCR-12-0307. View

18.

Fabi A, Nuzzo C, Vidiri A, Ciccarese M, Felici A, Cattani F . Bone and lung metastases from intracranial meningioma. Anticancer Res. 2006; 26(5B):3835-7. View

19.

Zhu J, Thakolwiboon S, Liu X, Zhang M, Lubman D . Overexpression of CD90 (Thy-1) in pancreatic adenocarcinoma present in the tumor microenvironment. PLoS One. 2014; 9(12):e115507. PMC: 4275230. DOI: 10.1371/journal.pone.0115507. View

20.

Williams A, Gagnon J . Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin. Science. 1982; 216(4547):696-703. DOI: 10.1126/science.6177036. View