Differential Responses of Trans-Resveratrol on Proliferation of Neural Progenitor Cells and Aged Rat Hippocampal Neurogenesis

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jun 24

PMID 27334554

Citations 30

Authors

Vivek Kumar

Ankita Pandey

Sadaf Jahan

Rajendra Kumar Shukla

Dipak Kumar

Akriti Srivastava

Shripriya Singh

Chetan Singh Rajpurohit

Sanjay Yadav

Vinay Kumar Khanna

Aditya Bhushan Pant

Affiliations

Soon will be listed here.

Abstract

The plethora of literature has supported the potential benefits of Resveratrol (RV) as a life-extending as well as an anticancer compound. However, these two functional discrepancies resulted at different concentration ranges. Likewise, the role of Resveratrol on adult neurogenesis still remains controversial and less understood despite its well documented health benefits. To gather insight into the biological effects of RV on neurogenesis, we evaluated the possible effects of the compound on the proliferation and survival of neural progenitor cells (NPCs) in culture, and in the hippocampus of aged rats. Resveratrol exerted biphasic effects on NPCs; low concentrations (10 μM) stimulated cell proliferation mediated by increased phosphorylation of extracellular signal-regulated kinases (ERKs) and p38 kinases, whereas high concentrations (>20 μM) exhibited inhibitory effects. Administration of Resveratrol (20 mg/kg body weight) to adult rats significantly increased the number of newly generated cells in the hippocampus, with upregulation of p-CREB and SIRT1 proteins implicated in neuronal survival and lifespan extension respectively. We have successfully demonstrated that Resveratrol exhibits dose dependent discrepancies and at a lower concentration can have a positive impact on the proliferation, survival of NPCs and aged rat hippocampal neurogenesis implicating its potential as a candidate for restorative therapies against age related disorders.

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References

Troy C, Friedman J, Friedman W . Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. J Biol Chem. 2002; 277(37):34295-302. DOI: 10.1074/jbc.M205167200. View

Learish R, Bruss M . Inhibition of mitogen-activated protein kinase kinase blocks proliferation of neural progenitor cells. Brain Res Dev Brain Res. 2000; 122(1):97-109. DOI: 10.1016/s0165-3806(00)00064-x. View

Howitz K, Bitterman K, Cohen H, Lamming D, Lavu S, Wood J . Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003; 425(6954):191-6. DOI: 10.1038/nature01960. View

Huang E, Reichardt L . Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 2001; 24:677-736. PMC: 2758233. DOI: 10.1146/annurev.neuro.24.1.677. View

Baur J . Resveratrol, sirtuins, and the promise of a DR mimetic. Mech Ageing Dev. 2010; 131(4):261-9. PMC: 2862768. DOI: 10.1016/j.mad.2010.02.007. View

Sun A, Wang Q, Simonyi A, Sun G . Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol Neurobiol. 2010; 41(2-3):375-83. PMC: 3076208. DOI: 10.1007/s12035-010-8111-y. View

van Praag H, Christie B, Sejnowski T, Gage F . Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A. 1999; 96(23):13427-31. PMC: 23964. DOI: 10.1073/pnas.96.23.13427. View

van Praag H, Kempermann G, Gage F . Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999; 2(3):266-70. DOI: 10.1038/6368. View

Kumar V, Gupta A, Shukla R, Tripathi V, Jahan S, Pandey A . Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity. Sci Rep. 2015; 5:14038. PMC: 4570211. DOI: 10.1038/srep14038. View

10.

Whitlock N, Baek S . The anticancer effects of resveratrol: modulation of transcription factors. Nutr Cancer. 2012; 64(4):493-502. PMC: 3349800. DOI: 10.1080/01635581.2012.667862. View

11.

Wang Z, Huang Y, Zou J, Cao K, Xu Y, Wu J . Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med. 2001; 9(1):77-9. View

12.

Li H, Xia N, Forstermann U . Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide. 2012; 26(2):102-10. DOI: 10.1016/j.niox.2011.12.006. View

13.

Chandravanshi L, Shukla R, Sultana S, Pant A, Khanna V . Early life arsenic exposure and brain dopaminergic alterations in rats. Int J Dev Neurosci. 2014; 38:91-104. DOI: 10.1016/j.ijdevneu.2014.08.009. View

14.

Campisi J . Aging, cellular senescence, and cancer. Annu Rev Physiol. 2012; 75:685-705. PMC: 4166529. DOI: 10.1146/annurev-physiol-030212-183653. View

15.

Fresno Vara J, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M . PI3K/Akt signalling pathway and cancer. Cancer Treat Rev. 2004; 30(2):193-204. DOI: 10.1016/j.ctrv.2003.07.007. View

16.

Pani G . Neuroprotective effects of dietary restriction: Evidence and mechanisms. Semin Cell Dev Biol. 2015; 40:106-14. DOI: 10.1016/j.semcdb.2015.03.004. View

17.

Dasgupta B, Milbrandt J . Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A. 2007; 104(17):7217-22. PMC: 1855377. DOI: 10.1073/pnas.0610068104. View

18.

Miloso M, Bertelli A, Nicolini G, Tredici G . Resveratrol-induced activation of the mitogen-activated protein kinases, ERK1 and ERK2, in human neuroblastoma SH-SY5Y cells. Neurosci Lett. 1999; 264(1-3):141-4. DOI: 10.1016/s0304-3940(99)00194-9. View

19.

Ming G, Song H . Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron. 2011; 70(4):687-702. PMC: 3106107. DOI: 10.1016/j.neuron.2011.05.001. View

20.

Lee J, Seroogy K, Mattson M . Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem. 2002; 80(3):539-47. DOI: 10.1046/j.0022-3042.2001.00747.x. View