Long Non-coding RNA HULC As a Novel Serum Biomarker for Diagnosis and Prognosis Prediction of Gastric Cancer

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Jun 21

PMID 27322075

Citations 62

Authors

Chunjing Jin

Wei Shi

Feng Wang

Xianjuan Shen

Jing Qi

Hui Cong

Jie Yuan

Linying Shi

Bingying Zhu

Xi Luo

Yan Zhang

Shaoqing Ju

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) have recently emerged as vital players in tumor biology with potential value in cancer diagnosis, prognosis, and therapeutics. The lncRNA HULC (highly up-regulated in liver cancer) is increased in many malignancies, yet its serum expression profile and clinical value in gastric cancer (GC) patients remain unclear. Quantitative real-time polymerase chain reaction (RT-qPCR) for large-scale analysis of the serum expression of HULC in GC patients reliably detected circulating HULC and revealed that it is upregulated in GC patients. A high serum HULC level correlated with tumor size, lymph node metastasis, distant metastasis, tumor-node-metastasis stage, and H. pylori infection. The area under the ROC curve for HULC was up to 0.888, which was higher than that for CEA (0.694) and CA72-4 (0.514). Follow-up detection and Kaplan-Meier curve analysis revealed HULC is a good predictor of GC prognosis. Our present study indicates that circulating HULC may represent a novel serum tumor marker for early diagnosis and monitoring progression and prognosis of GC.

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