Ferroptosis: A Missing Puzzle Piece in the P53 Blueprint?

Overview

Journal Mol Cell Oncol

Specialty Oncology

Date 2016 Jun 18

PMID 27314071

Citations 12

Authors

Shang-Jui Wang

Yang Ou

Le Jiang

Wei Gu

Affiliations

Soon will be listed here.

Abstract

Recent evidence indicates that canonical functions of p53 (i.e., apoptosis and growth arrest) are dispensable for p53-mediated tumor suppression. We have uncovered a novel function of p53 that contributes to tumor suppression through regulation of cystine metabolism, reactive oxygen species responses, and ferroptosis. The p53-mediated ferroptotic response via SLC7A11 denotes an extra layer of defense against tumorigenesis in conjunction with other p53 functions.

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